NEUROBEHAVIORAL FEATURES--MESIAL TEMPORAL LOBE EPILEPSY

说明： 这项调查的目的是开发一个概念模型来 促进癫痫手术的最佳神经发育时机 发源于颞叶的复杂部分性癫痫患者最多 常见的局灶性切除(前颞叶切除术)。这 研究调查了持续时间和严重性增加的程度 癫痫与以下因素有关：1)解剖结构的存在和程度 初级(同侧)以外的神经区异常(萎缩) 致痫的海马区，2)癫痫的存在和损害程度 对侧记忆功能和一般神经心理能力， 两者都表明初级(同侧)以外的神经区域受损 致痫的海马体，以及3)健康相关的损害程度 生活质量。受试组包括：1)150名早期(&lt；14)患者 年)复发性复杂部分性癫痫发作的年龄 按时间顺序计算的年龄为14-40岁，因此具有相当大的变异性 癫痫的持续时间和严重程度；2)75岁和性别匹配 控制。患者和对照组将接受定量MRI体积测量 选定的感兴趣区域，全面的神经心理学 健康相关生活质量的评估、评估和标准化 面试。假设持续时间的增加，但特别是 癫痫的严重程度(例如，癫痫发作数年而未持续发作 缓解、癫痫持续状态发作次数、终生继发次数 全身性强直-阵挛发作)将与 与解剖、神经心理和健康相关的生活质量的证据 减损。

DESCRIPTION: The purpose of this investigation is to develop a conceptual model to facilitate the optimal neurodevelopmental timing of epilepsy surgery for patients with complex partial seizures of temporal lobe origin, the most common candidates for focal resection (anterior temporal lobectomy). This study investigates the degree to which increasing duration and severity of epilepsy are associated with: 1) the presence and degree of anatomic abnormality (atrophy) in neural regions outside the primary (ipsilateral) epileptogenic hippocampus, 2) the presence and degree of impairments in contralateral memory function and generalized neuropsychological ability, both suggesting damage to neural regions outside the primary (ipsilateral) epileptogenic hippocampus, and 3) degree of impairment to health-related quality of life. Subject groups include: 1) 150 patients with early (< 14 years) age of recurrent onset of complex partial seizures between the chronological ages of 14-40 years, thus with considerable variability as to the duration and severity of epilepsy; and 2)75 age and sex matched controls. Patients and controls will undergo quantitative MRI volumetrics of selected regions of interest, comprehensive neuropsychological assessment, evaluation of health-related quality of life, and standardized interview. It is hypothesized that increasing duration but especially severity of epilepsy (e.g., years of epilepsy without sustained periods of remission, episodes of status epilepticus, lifetime number of secondary generalized tonic-clonic seizures) will be significantly associated with evidence of anatomic, neuropsychological, and health-related quality of life impairments.