NEUROBEHAVIORAL FEATURES--MESIAL TEMPORAL LOBE EPILEPSY

神经行为特征——内侧颞叶癫痫

• 批准号: 6188066
• 负责人: Bruce Phillip Hermann
• 金额: $ 33.64万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6188066
• 关键词: adolescence (12-20); behavioral /social science research tag; clinical research; developmental neurobiology; disease /disorder onset; hippocampus; human subject; magnetic resonance imaging; memory disorders; neuropathology; neuropsychological tests; neuropsychology; neurosurgery; partial seizure; quality of life; relapse /recurrence; temporal lobe /cortex disorder; young adult human (21-34)

DESCRIPTION: The purpose of this investigation is to develop a conceptual model to facilitate the optimal neurodevelopmental timing of epilepsy surgery for patients with complex partial seizures of temporal lobe origin, the most common candidates for focal resection (anterior temporal lobectomy). This study investigates the degree to which increasing duration and severity of epilepsy are associated with: 1) the presence and degree of anatomic abnormality (atrophy) in neural regions outside the primary (ipsilateral) epileptogenic hippocampus, 2) the presence and degree of impairments in contralateral memory function and generalized neuropsychological ability, both suggesting damage to neural regions outside the primary (ipsilateral) epileptogenic hippocampus, and 3) degree of impairment to health-related quality of life. Subject groups include: 1) 150 patients with early (< 14 years) age of recurrent onset of complex partial seizures between the chronological ages of 14-40 years, thus with considerable variability as to the duration and severity of epilepsy; and 2)75 age and sex matched controls. Patients and controls will undergo quantitative MRI volumetrics of selected regions of interest, comprehensive neuropsychological assessment, evaluation of health-related quality of life, and standardized interview. It is hypothesized that increasing duration but especially severity of epilepsy (e.g., years of epilepsy without sustained periods of remission, episodes of status epilepticus, lifetime number of secondary generalized tonic-clonic seizures) will be significantly associated with evidence of anatomic, neuropsychological, and health-related quality of life impairments.

产品说明： 本研究的目的是建立一个概念模型， 促进癫痫手术的最佳神经发育时机， 颞叶起源的复杂部分性发作患者， 病灶切除术（前颞叶切除术）的常见候选者。 这 研究调查了持续时间和严重程度增加的程度， 癫痫与：1）解剖结构的存在和程度 原发灶（同侧）外神经区域异常（萎缩） 致痫性海马，2）存在和程度的损害， 对侧记忆功能和广义神经心理学能力， 这两种情况都表明原发灶（同侧）以外的神经区域受损 致痫性海马，以及3）对健康相关的损害程度 生活质量 受试者组包括：1）150例早期（< 14 复杂部分性癫痫发作的复发年龄 年龄在14-40岁之间，因此， 癫痫的持续时间和严重程度; 2）75例年龄和性别匹配的患者 对照 患者和对照组将接受定量MRI体积测量 选择感兴趣的区域，全面的神经心理学 健康相关生活质量的评估和标准化 采访 据推测，增加持续时间，特别是 癫痫的严重程度（例如，年癫痫无持续期 缓解，癫痫持续状态发作次数，继发性 全身强直阵挛发作）将与 解剖学、神经心理学和健康相关生活质量的证据 损伤