NEUROBEHAVIORAL FEATURES OF MESIAL TEMPORAL LOBE EPILEPSY

内侧颞叶癫痫的神经行为特征

• 批准号: 7375496
• 负责人: Bruce Phillip Hermann
• 金额: $ 0.84万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375496
• 关键词: NEUROBEHAVIORAL; FEATURES; MESIAL; TEMPORAL; LOBE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (from CRISP website) We are proposing the first prospective investigation designed to detect progressive adverse effects of chronic early onset (less than age 14) temporal lobe epilepsy (TLE) on brain structure and function. This proposed study will combine high- resolution quantitative MRI volumetrics, comprehensive neuropsychological assessment, and an fMRI memory activation task. The purpose of this investigation is to test the hypothesis that early onset TLE is associated with a generalized adverse neurodevelopmental impact on both brain structure and function. If this is proven, that may constitute an early-acquired neurobiological vulnerability for progressive cognitive decline in the face of ongoing chronic epilepsy. We will do a longitudinal examination of 80 early onset TLE subjects and 80 age and gender matched controls that were initially seen for baseline testing four to five years earlier. All subjects will again undergo cognitive assessment and whole brain quantitative MRI volumetrics and a subset of subjects will undergo an fMRI object memory task. It is predicted that: (1) cognitive decline in this four-five year interval will be greater for early onset TLE subjects compared to controls, (2) decline will be most evident among those with longer duration of epilepsy, and for measures of memory function, speeded cognitive processing and non-verbal abilities compared to language based tasks, (3) test-retest cognitive decline shown by early onset TLE subjects will be predicted by time total brain tissue volume and proportional brain tissue lost over the test- retest interval, and (4) increasing chronicity of epilepsy will be associated with decreasing mesial temporal lobe activation on an fMRI object memory task. Additional analyses will examine the impact of specific epilepsy course variables, depression, and associated chronic medical illness on longitudinal changes in TLE.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。(from CRISP网站）我们提出了第一个前瞻性研究，旨在检测慢性早发性（小于14岁）颞叶癫痫（TLE）对大脑结构和功能的进行性不良影响。这项拟议的研究将结合联合收割机高分辨率定量磁共振成像体积，全面的神经心理学评估，和功能磁共振成像记忆激活任务。本研究的目的是检验这一假设，即早发性TLE与对大脑结构和功能的普遍不良神经发育影响有关。如果这一点得到证实，这可能构成了一个早期获得的神经生物学脆弱性，在面对持续的慢性癫痫时进行性认知下降。我们将对80名早发性TLE受试者和80名年龄和性别匹配的对照者进行纵向检查，这些受试者最初是在四到五年前进行基线测试的。所有受试者将再次接受认知评估和全脑定量MRI体积测量，一部分受试者将接受fMRI对象记忆任务。据预测：（1）与对照组相比，早发性TLE受试者在这4 - 5年间隔内的认知下降将更大，（2）在癫痫持续时间较长的受试者中，以及与基于语言的任务相比，对于记忆功能、加速认知处理和非语言能力的测量，下降将最明显，（3）由早发TLE受试者显示的测试-再测试认知下降将通过在测试-再测试间隔内总脑组织体积和比例脑组织损失的时间来预测，（4）癫痫慢性化程度的增加与fMRI物体记忆任务中内侧颞叶激活的减少有关。 其他分析将检查特定癫痫病程变量、抑郁症和相关慢性疾病对TLE纵向变化的影响。