AIRWAY PERFUSION ASSISTED LIQUID VENTILATOR

气道灌注辅助液体呼吸机

• 批准号: 2767970
• 负责人: JAMES Courtney PARKER
• 金额: $ 10.5万
• 依托单位: MALLARD MEDICAL CO., INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2767970
• 关键词: fluid; fluosol; histology; perfusion; respirators; respiratory airway clearance; respiratory airway volume; respiratory disorder chemotherapy; respiratory insufficiency /failure; swine; technology /technique development

DESCRIPTION (adapted from applicant's abstract): Ventilation with perfluorocarbon (PFC) liquids preserves the lungs and maintains gas exchange during end-stage adult and infant respiratory failure. The applicants propose to develop a new type of liquid ventilator with greatly enhanced gas exchange capability. The ventilator uses a recently patented mode of liquid delivery which circumvents the gas exchange limitation imposed by the slower diffusion of gases in PFC liquid, compared to air. A continuous intratracheal circulation of PFC liquid through a double lumen catheter with superimposed delivery of liquid tidal volume removes airway dead space ventilation and facilitates respiratory gas diffusion through airway eddy currents. Preliminary data in piglets indicate an increase in CO2 clearance using this mode of liquid delivery. During phase I, Mallard Medical Company which has extensive experience in ventilator development and production, will develop and deliver a prototype ventilator with high output capability and precise wave form control. The investigators propose to optimize ventilatory parameters to maximize CO2 clearance and compare maximal CO2 clearances and blood gas values between the new mode of ventilation and conventional tidal liquid ventilation in newborn piglets. They will also ventilate piglets for 6 hours at optimal settings and examine the lungs for histologic evidence of tissue injury. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述(改编自申请人的摘要)：通风 全氟化碳(PFC)液体保护肺部并维持气体交换 在成人和婴儿呼吸衰竭末期。申请者提议 大力加强气体交换的新型液体通风机的研制 能力。呼吸机采用了一种最近获得专利的液体输送方式 这绕过了由较慢的扩散所施加的气体交换限制 与空气相比，PFC液体中的气体。持续的气管内循环 经双腔导管叠加输送的PFC液体 液体潮气量消除呼吸道死腔通气量 呼吸道气体通过呼吸道涡流扩散。第一季度初步数据 仔猪表示，使用这种液体模式可以增加二氧化碳的清除量 送货。在第一阶段，野鸭医疗公司拥有广泛的 在呼吸机开发和生产方面的经验，将开发和交付 具有高输出能力和精确波形控制的原型通风机。 研究人员建议优化通风参数以最大限度地增加二氧化碳 清除量和比较最大二氧化碳清除量和血气值 新生儿新型呼吸机模式与常规潮气液呼吸机的比较 小猪。他们还将在最佳设置下为小猪通风6小时，并 检查肺部是否有组织损伤的组织学证据。 建议的商业应用：不可用