Human and Mouse Artificial Lymph Nodes: Novel technology to Reduce and Replace the use of animal models in clinical and developmental immunology

人类和小鼠人工淋巴结：减少和取代临床和发育免疫学中动物模型使用的新技术

• 批准号: NC/K000527/1
• 负责人: Mark Coles
• 金额: $ 53.39万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NC%2FK000527%2F1
• 关键词: Human; Mouse; Artificial; Lymph; Nodes

The treatment of autoimmune and inflammatory disease has a major impact on the NHS and society and is estimated to cost the UK over 20 billion pounds per year. New treatments are required to treat these debilitating disorders. Currently, the development of novel therapeutics involves using rodent models of the disease and testing in non-human primates before initiating clinical trials in humans. This process utilises large numbers of animals, is expensive and is not necessarily very informative in how a treatment might work in humans. In this proposal in collaborate with a pharmaceutical manufactoring and testing organisation, ProBioGen Ag, we will develop and utilise a new technology we have termed an artificial human lymph nodes to replicate the human immune system in a test tube. This system will allow replacement of animals in the drug development process and reduction in animal numbers required to do basic research into how the immune system develops and functions.

自身免疫性和炎症性疾病的治疗对NHS和社会产生重大影响，估计每年花费英国超过200亿英镑。需要新的治疗方法来治疗这些使人衰弱的疾病。目前，新疗法的开发涉及使用该疾病的啮齿动物模型，并在启动人类临床试验之前在非人类灵长类动物中进行测试。这个过程使用大量的动物，是昂贵的，并不一定是非常有用的信息，在如何治疗可能在人类中工作。在这项提案中，我们将与制药和测试组织ProBioGen Ag合作，开发和利用一种新技术，我们称之为人工人类淋巴结，在试管中复制人类免疫系统。该系统将允许在药物开发过程中替换动物，并减少对免疫系统如何发展和发挥作用进行基础研究所需的动物数量。