COCAINE CRAVING AND COPING IN TREATMENT AND RELAPSE

描述：(申请人摘要) 由于渴望是许多药物使用、滥用和复发模式的核心， 关于渴望(使用的冲动)在寻求毒品行为中的作用的研究 对完善成瘾理论和开发有效的成瘾有重要意义 治疗创新。这项研究计划的长期目标是 就是增加一系列心理和行为方面的知识 参与维持可卡因的使用和滥用的进程，以开发 针对可卡因滥用的更有效的治疗方法。整体而言 此应用程序的目标是添加有关以下内容的知识库 使用可卡因冲动的决定因素和后果。这个项目是 在多年理论驱动的基础上发展起来的类似 对酗酒者和吸烟者进行的关于吸烟的决定因素的研究 冲动及其在治疗结果中的作用。该计划的主要具体目标 目前的应用是：1)确定自我报告的程度 入院时在可卡因风险评估中使用可卡因的冲动 治疗是一种前处理、药物使用和其他个人的功能 差异包括可卡因的使用模式(持续时间、频率、路线 管理、问题严重性)、其他药物使用(酒精诊断、 酒精使用频率、其他药物使用频率)、预期影响 可卡因，以及性别、种族、年龄或反社会人格诊断。2)至 确定报告的可卡因使用冲动的程度 入院治疗时的可卡因风险评估是预测 3个月和6个月随访时的治疗磨耗和治疗结果 同时控制可卡因使用前的变量。次要的 具体目标是：3)确定不同可卡因的程度 复发沉淀物与吸食可卡因的冲动有不同的联系 在雪上加霜的情况下报道。4)回溯调查 不同催促应对策略的实施率是否存在差异 根据复发和禁欲的情况进行随访。可卡因 吸毒者(150名参与者)将从药物滥用部分招募 医院治疗计划，以在 入院第一周。所有人都将接受第三人和第六人的面试 在部分医院计划出院后几个月确定 可卡因的使用频率和首次使用的时间， 复发，以及报告的应对使用冲动的技能。结果将是 用来增加对可卡因滥用和复发的理论理解，以及 可能会为开发未来的治疗方案提供有用的信息。

DESCRIPTION: (Applicant's Abstract) As craving is central to many models of substance use, abuse and relapse, studies of the role of craving (urge to use) in drug seeking behavior are important for refining theories of addiction and developing effective treatment innovations. The long-term objective of this program of research is to increase knowledge about a range of psychological and behavioral processes involved in maintaining cocaine use and abuse so as to develop more effective treatment approaches for cocaine abuse. The overall objective of this application is to add to the knowledge base about determinants and consequences of urges to use cocaine. This project is developed on the foundation of many years of theoretically driven similar research conducted with alcoholics and smokers about the determinants of urges and their role in treatment outcome. The primary specific aims of the present application are: 1) To determine the extent to which self-reported urge to use cocaine during a cocaine risk assessment on admission to treatment is a function of pretreatment drug use and other individual differences including cocaine use patterns (duration, frequency, route of administration, problem severity), other drug use (alcohol diagnosis, frequency of alcohol use, frequency of other drug use), expected effects of cocaine, and gender, race, age or antisocial personality diagnosis. 2) To determine the extent to which amount of urge to use cocaine reported in a cocaine risk assessment on admission to treatment is a predictor of treatment attrition and of treatment outcome at 3 and 6 month follow-ups while controlling for pretreatment cocaine use variables. Secondary specific aims are: 3) To determine the extent to which different cocaine relapse precipitants are differentially associated with urges to use cocaine reported in the precipitating situation. 4) To investigate retrospectively whether the rate of implementing various urge coping strategies differs at follow up as a function of relapsed versus abstinent status. Cocaine abusers (150 participants) will be recruited from a substance abuse partial hospital treatment program to complete a battery of assessments within the first week of admission. All will receive interviews in person 3 and 6 months after discharge from the partial hospital program to determine frequency of cocaine use and time to first use, situations that precipitated relapse, and skills reported for coping with urges to use. Results will be used to add to theoretical understandings of cocaine abuse and relapse, and may provide information useful for developing future treatment programs.