Development and validation of a latent tuberculosis diagnostic

潜伏性结核病诊断的开发和验证

• 批准号: nhmrc : 1118550
• 负责人: Dr John Zaunders
• 金额: $ 36.5万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-validation-latent-tuberculosis-diagnostic/946333
• 关键词: Development; validation; latent; tuberculosis; diagnostic

Globally, tuberculosis is a leading cause of death with 9.6 million new diagnoses in 2014. The diagnosis of latent TB infection is important, but is difficult to make because current assays are suboptimal. We have developed a very simple assay which detects responses to TB antigens by co-expression of two surface markers expressed by CD4+ T cells. We propose to develop this into a highly standardised kit for the diagnosis of TB with our commercial partner Cytognos.

在全球范围内，结核病是导致死亡的主要原因，2014 年新增诊断人数为 960 万。潜伏性结核感染的诊断很重要，但由于目前的检测方法不够理想，诊断起来很困难。我们开发了一种非常简单的检测方法，通过 CD4+ T 细胞表达的两种表面标记物的共表达来检测对结核抗原的反应。我们建议与我们的商业合作伙伴 Cytognos 一起将其开发成高度标准化的结核病诊断试剂盒。