Development and validation of a latent tuberculosis diagnostic

在全球范围内，结核病是主要的死亡原因，2014年新诊断病例为960万例。潜伏性结核病感染的诊断很重要，但很难做出，因为目前的检测方法并不理想。我们已经开发了一种非常简单的检测方法，它通过共表达由CD4+T细胞表达的两个表面标志来检测对TB抗原的反应。我们建议与我们的商业合作伙伴Cytognos一起将其开发成高度标准化的结核病诊断试剂盒。

Globally, tuberculosis is a leading cause of death with 9.6 million new diagnoses in 2014. The diagnosis of latent TB infection is important, but is difficult to make because current assays are suboptimal. We have developed a very simple assay which detects responses to TB antigens by co-expression of two surface markers expressed by CD4+ T cells. We propose to develop this into a highly standardised kit for the diagnosis of TB with our commercial partner Cytognos.