Memory CD4 T cells that harbour the reservoir of latent HIV infection: their antigen specificity, function and frequency of antigen-driven reactivation

目前针对HIV的抗逆转录病毒疗法成功地抑制了病毒的产生，但不能完全将病毒从体内清除。该项目将提供有关记忆CD4 T细胞的基本信息，这些T细胞将HIV以潜在的DNA形式保留下来。记忆性CD4 T细胞可以非常长寿，并且这些潜伏感染的记忆细胞可以在治疗中断期间产生病毒。我们将使用一种新的方法来鉴定哪些记忆性CD4 T细胞含有潜伏的HIV DNA。

Current antiretroviral therapy for HIV successfully suppresses virus production, but does not completely eliminate the virus from the body. This project will provide essential information on memory CD4 T cells that retain HIV in a latent DNA form. Memory CD4 T cells can be very long-lived, and these latently infected memory cells can give rise to virus during treatment interruption. We will use a novel method to identify which memory CD4 T cells contain latent HIV DNA.