Memory CD4 T cells that harbour the reservoir of latent HIV infection: their antigen specificity, function and frequency of antigen-driven reactivation

储存潜伏 HIV 感染的记忆 CD4 T 细胞：其抗原特异性、功能和抗原驱动再激活的频率

• 批准号: nhmrc : 1010185
• 负责人: Dr John Zaunders
• 金额: $ 30.26万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/memory-cd4-t-driven-reactivation/109468
• 关键词: Memory; CD4; cells; harbour; reservoir

Current antiretroviral therapy for HIV successfully suppresses virus production, but does not completely eliminate the virus from the body. This project will provide essential information on memory CD4 T cells that retain HIV in a latent DNA form. Memory CD4 T cells can be very long-lived, and these latently infected memory cells can give rise to virus during treatment interruption. We will use a novel method to identify which memory CD4 T cells contain latent HIV DNA.

目前针对HIV的抗逆转录病毒疗法成功地抑制了病毒的产生，但不能完全将病毒从体内清除。该项目将提供有关记忆CD4 T细胞的基本信息，这些T细胞将HIV以潜在的DNA形式保留下来。记忆性CD4 T细胞可以非常长寿，并且这些潜伏感染的记忆细胞可以在治疗中断期间产生病毒。我们将使用一种新的方法来鉴定哪些记忆性CD4 T细胞含有潜伏的HIV DNA。