Processes underlying establishment and maintenance of the latent HIV resevoir and potential impact of integrase inhibitors

潜在 HIV 储存库建立和维持的基本过程以及整合酶抑制剂的潜在影响

• 批准号: nhmrc : 510325
• 负责人: Dr John Zaunders
• 金额: $ 21.21万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/processes-underlying-establishment-integrase-inhibitors/77563
• 关键词: Processes; underlying; establishment; maintenance; latent

Therapy for HIV-infected individuals is currently able to control the growth of the virus, but cannot eradicate the viral infection. This is due to a pool of CD4+ T lymphocytes which contain HIV DNA in a latent state, ready to reactivate as soon as therapy is interrupted. This project aims to better understand how this pool of latently infected CD4+ T lymphocytes is established and maintained, particularly how it is linked to the essential T cell survival signal from interleukin 7.

目前对艾滋病毒感染者的治疗能够控制病毒的生长，但不能根除病毒感染。这是由于含有HIV DNA的CD4+ T淋巴细胞池处于潜伏状态，一旦治疗中断就准备重新激活。该项目旨在更好地了解这种潜伏感染的CD4+ T淋巴细胞库是如何建立和维持的，特别是它如何与白细胞介素7的基本T细胞存活信号相关联。