Human tissue models for lung disease

需要进行更多的研究，以确定治疗哮喘和慢性阻塞性肺病等肺部疾病的有效和安全的疗法。目前大部分的研究工作都是在动物模型中进行的。然而，由于哮喘等疾病是一种独特的人类疾病，有时很难解释动物模型中产生的数据，并以合乎逻辑的方式将获得的知识应用于人类疾病过程。最近的一项调查表明，需要使用新鲜的人体组织样本进行肺部研究。获得这类组织的主要障碍似乎是缺乏分配人体组织的基础设施和程序，而这些组织已被同意将死者捐献的组织用于研究。目前，全国各地的医院正在处理大量人体组织。学术界与国家卫生服务血液和移植组织和眼科服务之间的战略合作可以为英国科学界获得完全符合伦理的人类正常和患病肺组织开辟一条途径，从而减少研究中对动物组织的需求。这项合作将研究肺组织，但它可以扩展到几乎包括身体的每一个组织/器官类型。通过对人体组织的研究，已经发现了宝贵的信息，从而导致人类疾病的治疗，并且在没有从动物组织中观察到的结果的不成功的临床试验中节省了无数的时间、精力和金钱。然而，目前在英国，获得完整的人体肺组织用于研究几乎是不可能的。NHS血液和移植、组织和眼科服务（TES）处于独特的地位，可以获得伦理同意的人体组织进行移植和研究。TES可以在死亡后48小时内提取组织用于临床目的，目前每年从400名死者供体中提取组织。此外，TES有能力同意仅用于研究的捐赠者，包括患有特定疾病的捐赠者。通过这种方式，TES可以为科学界提供正常和病变组织。我们的目标是在肺回收后的一段时间内，利用一系列标准生物测定系统，调查来自8个研究小组和3所大学的肺组织的生存能力。我们将提供有关监管障碍的信息，如何获取这些资源，有关原代细胞/组织活力的数据，所有这些都将作为指导提供给科学界。

More research is required to identify effective and safe therapeutics for the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease. Much of the research effort currently is carried out in animal models. However, because diseases such as asthma are a uniquely human condition it is sometimes difficult to interpret data generated in animal models and apply the knowledge gained in a logical way to the human disease process. A recent survey identified a need to use fresh human tissue samples for lung research. The major obstacle to obtaining tissues of this sort appears to be the lack of infrastructure and process for distributing the human tissue were consent has been given for deceased donor tissue to be used for research. Currently a significant amount of human tissue is being disposed of in hospitals all over the country. A strategic collaboration between academics and the National Health Service Blood and Transplant Tissue and Eye Services could open up a pathway to obtain fully ethically consented, human normal and diseased lung tissue to the UK scientific community thereby reducing the need for animal tissue in research. This collaboration will investigate lung tissue but it could be expanded to include almost every tissue/organ type in the body.Invaluable information has been discovered leading to therapies for human disease through the study of human tissues and an infinite amount of time, effort and money saved on unsuccessful clinical trials where observations have not translated from animal tissue. However, obtaining intact human lung tissue for research is currently virtually impossible in the UK. NHS Blood and Transplant, Tissue and Eye Services (TES) are in the unique position of having access to ethically consented human tissue for transplantation and research. TES can retrieve tissue up to 48 hours after death for clinical purposes and currently obtains tissue from 400 deceased donors per year. In addition, TES has the capability to consent for research-only donors, including those with specific diseases. In this way, TES may be in a position to offer normal and diseased tissue to the scientific community. We aim to investigate the viability of lung tissues from this resource across 8 research groups and 3 universities utilising a range of standard bioassay systems at periods of time after lung retrieval. We will provide information regarding the regulatory barriers, how to access this resource, data regarding the viability of primary cells/tissues and all this will be made available to the scientific community as a guide.