EPIDEMIOLOGY OF GALLBLADDER SLUDGE & STONES IN PREGNANCY

胆囊淤泥的流行病学

• 批准号: 6138010
• 负责人: SUM P LEE
• 金额: $ 31.88万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6138010
• 关键词: age difference; biliary tract disorder diagnosis; cholelithiasis; clinical research; disease /disorder proneness /risk; epidemiology; estradiol; female; gallbladder disorder; gender difference; human pregnant subject; hyperinsulinism; hyperlipidemia; interview; longitudinal human study; obesity; postpartum; pregnancy; progesterone; ultrasonography

DESCRIPTION: (Adapted from Investigator's Abstract) Without exception, cholesterol gallstone is more common among women than men in every population studied. This consistent and conspicuous gender difference starts during puberty, continues throughout the childbearing years, but fades alter menopause. Biliary sludge, a newly described ultrasonographic diagnosis, is a mixture of cholesterol monohydrate crystals and other precipitates within the gallbladder, and it is regarded as a precursor form of gallstones. Sludge is frequently found in pregnant women, although the risk factors for the development of gallbladder sludge and stones during pregnancy have not been clearly defined. The investigators propose a prospective investigation of gallstones and biliary sludge that develop during pregnancy to accomplish several specific aims. First, they will determine the incidence rate of biliary sludge and gallstones during pregnancy and compare this rate to a nonpregnant control sample. Second, they will look for factors predictive of the development of biliary sludge gallstones during pregnancy, including obesity, age, hyperinsulinemia, hyperlipidemia and serum estradiol and progesterone levels. Lastly, they will examine predictors of persistent gallstones and biliary sludge disease in the postpartum period by following women until one year after delivery. They aim to include as many as 7,280 women in this study. They will be recruited from the prenatal and genealogy clinics of Madigan Army Hospital. Development of gallstones and biliary sludge will be defined by ultrasonographic examination of the gallbladder contents performed at pre-specified intervals during gestation and postpartum, and at an equivalent time in the non-pregnant control group. A variety of analytic methods will be used to achieve these specific aims of this study. Gallstone and biliary sludge are common in women and represent major causes of morbidity. The investigators state that this study will add new and important insight into the risk factors leading to these outcomes and affecting their natural history. They further note that this information, in turn, may lead to effective strategies for treatment and prevention of these conditions.

描述：（改编自研究者摘要）无一例外， 胆固醇胆结石在各方面女性比男性更常见 研究人群。这种一致且明显的性别差异 从青春期开始，持续整个育龄期，但是 褪色改变更年期。胆泥，一种新描述的超声检查 诊断，是一水胆固醇晶体和其他物质的混合物 胆囊内沉淀，被视为前体 胆结石的形式。孕妇身上经常会出现污泥， 尽管胆囊淤泥形成的危险因素和 妊娠期结石尚未明确定义。 研究人员提议对胆结石进行前瞻性调查 怀孕期间形成的胆泥可以完成多种任务 具体目标。首先，他们将确定胆汁的发生率 怀孕期间的污泥和胆结石，并将该比率与 非妊娠对照样品。其次，他们会寻找因素 预测胆泥胆结石的发展 怀孕，包括肥胖、年龄、高胰岛素血症、高脂血症和 血清雌二醇和孕酮水平。 最后，他们将检查 持续性胆结石和胆泥病的预测因素 产后期跟踪妇女直至产后一年。他们 这项研究的目标是包括多达 7,280 名女性。 他们将是 从马迪根陆军的产前和家谱诊所招募 医院。胆结石和胆泥的形成将被定义 通过对胆囊内容物进行超声检查 在妊娠期间和产后期间按照预先指定的时间间隔进行 与非怀孕对照组的时间相当。多种解析 将使用方法来实现本研究的这些具体目标。 胆结石和胆泥在女性中很常见，是主要的疾病 发病原因。研究人员表示，这项研究将添加 对导致这些风险因素的新的重要见解 结果并影响其自然史。他们进一步指出 这些信息反过来可能会导致制定有效的战略 治疗和预防这些病症。