The effect of physical activity on metabolic syndrome in pregnancy and fetal outc

体力活动对妊娠期代谢综合征及胎儿结局的影响

• 批准号: 7197667
• 负责人: SUM P LEE
• 金额: $ 13.11万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7197667
• 关键词: Adipose tissue; Attenuated; Body mass index; Cardiovascular Diseases; Central obesity; Cirrhosis; Deposition; Development; Diabetes Mellitus; Exercise; Fasting; Fatty acid glycerol esters; Feasibility Studies; Fetal Development; Future; Gestational Diabetes; Glucose; Growth; Health; Hepatocyte; High Density Lipoprotein Cholesterol; Hypertension; Hypertriglyceridemia; Infant Health; Inflammation; Insulin; Insulin Resistance; Intra-abdominal; Lead; Leptin; Link; Lipids; Liver diseases; Maternal Health; Measures; Metabolic; Metabolic syndrome; Methods; Morbidity - disease rate; Mothers; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outcome Study; Overweight; Parents; Physical activity; Physiological; Physiological Adaptation; Pilot Projects; Postpartum Period; Predisposing Factor; Pregnancy; Pregnant Women; Prevalence; Public Health; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Risk Factors; Serum; Staging; Structure; Syndrome; United States; Waist-Hip Ratio; Weight Gain; Weight maintenance regimen; Woman; fetal; impaired glucose tolerance; improved; insulin sensitivity; men; mortality; non-alcoholic fatty liver; programs; sedentary; waist circumference

DESCRIPTION (provided by applicant): Overweight and obesity are increasing public health concerns in the United States. A correlate of overweight and obesity, the metabolic syndrome, is a significant risk factor for cardiovascular disease, diabetes mellitus, and is a risk factor for increased all-cause mortality. Central adiposity, as measured by waist circumference or waist-hip ratio, is a key factor predisposing to the metabolic syndrome. One potential underlying pathogenic factor for the metabolic syndrome is insulin resistance. During pregnancy, insulin sensitivity is decreased, frequently leading to the development of gestational diabetes. Gestational diabetes is associated with significant increases in maternal complications and fetal morbidity, as well as being a risk factor for later development of type II diabetes mellitus. Physical activity during pregnancy may be beneficial in increasing insulin sensitivity and in managing gestational diabetes. Weight gained during pregnancy, at least in part due to increases in insulin resistance, is commonly retained after pregnancy and may lead to future overweight, obesity, and the metabolic syndrome. In men and non- pregnant women, physical activity may lead to decreases in central adiposity and improvement in insulin sensitivity. We hypothesize that increasing physical activity during pregnancy may attenuate the increases in central adiposity and the physiological decrease in insulin sensitivity during pregnancy, potentially leading to improved metabolic parameters both during and after pregnancy and improved maternal and fetal outcomes. We propose pilot studies, linked to an ongoing randomized controlled trial of exercise in pregnancy, to inform a larger study of these outcomes. The specific aims of this study are: 1) to determine whether a structured program of moderate to vigorous exercise in pregnancy leads to decreased central adiposity in the postpartum; and 2) to examine the feasibility of studying fetal outcomes in the parent randomized trial. This study will be important in finding methods to help women avoid excessive weight gain during and after pregnancy, and in reducing the long-term potential health effects of pregnancy. It may offer a safe and readily available method to control weight and improve infant health during and after pregnancy.

描述（由申请人提供）： 超重和肥胖正在增加美国的公共卫生问题。与超重和肥胖相关的代谢综合征是心血管疾病、糖尿病的重要危险因素，也是全因死亡率增加的危险因素。以腰围或腰臀比测量的中心性肥胖是诱发代谢综合征的关键因素。代谢综合征的一个潜在的潜在致病因素是胰岛素抵抗。在怀孕期间，胰岛素敏感性降低，经常导致妊娠糖尿病的发展。妊娠糖尿病与母体并发症和胎儿发病率的显著增加有关，并且是以后发展为II型糖尿病的危险因素。怀孕期间的体力活动可能有利于增加胰岛素敏感性和管理妊娠期糖尿病。怀孕期间体重增加，至少部分是由于胰岛素抵抗增加，通常在怀孕后保留，并可能导致未来超重，肥胖和代谢综合征。在男性和非妊娠女性中，体力活动可能导致中心性肥胖减少和胰岛素敏感性改善。我们假设，在怀孕期间增加体力活动可能会减弱增加的中心性肥胖和生理性降低胰岛素敏感性在怀孕期间，可能会导致改善代谢参数在怀孕期间和怀孕后，改善母亲和胎儿的结果。我们建议进行试点研究，与正在进行的妊娠期运动随机对照试验相关联，以告知这些结果的更大研究。本研究的具体目的是：1）确定在妊娠期进行中度至剧烈运动的结构化计划是否会导致产后中心性肥胖减少; 2）检查在父母随机试验中研究胎儿结局的可行性。这项研究对于寻找方法帮助女性避免怀孕期间和怀孕后体重过度增加以及减少怀孕对健康的长期潜在影响非常重要。它可以提供一个安全和现成的方法来控制体重和改善婴儿的健康在怀孕期间和之后。