HIV STRUCTURAL GENE VECTORS--LIVE-ATTENUATED HIV VACCINE

HIV结构基因载体--HIV减毒活疫苗

• 批准号: 6170687
• 负责人: Kathleen A. Boris-Lawrie
• 金额: $ 21.9万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6170687
• 关键词: AIDS vaccines; Macaca mulatta; T lymphocyte; attenuated microorganism; clinical research; human immunodeficiency virus; human tissue; simian immunodeficiency virus; structural genes; tissue /cell culture; vaccine development; vector vaccine; virus replication

DESCRIPTION: (Adapted from Applicant's Abstract) This application will attempt to derive HIV structural gene vectors (SGV) and to evaluate their infectivity and immunogenicity both in vitro and in vivo. The investigator will define the minimal combination of HIV accessory genes that are required for efficient replication in cultured and in primary human T-cells and in primary monkey T-cells and finally to evaluate infectivity and immunogenicity of SIV SGV in the macaque model.

描述：(改编自申请者摘要)此申请将尝试 构建人类免疫缺陷病毒结构基因载体(SGV)并评价其传染性 以及体外和体内的免疫原性。调查员将定义 高效所需的HIV辅助基因的最小组合 原代培养人T细胞和原代猴T细胞的复制 T细胞，最后评价SIV SGV的感染性和免疫原性。 猕猴模型。