CONFERENCE--SMALL GENOMES 2000

这项提案是为将于2000年9月24-28日在加利福尼亚州箭头湖的会议中心举行的第八届小基因组会议(前身为E.Coli和小基因组会议)提供会议赠款。在接下来的一两年里，人们对比较多达50个微生物基因组的序列和内容的前景感到非常兴奋。微生物学的不同方面无疑将发生相当大的整合，包括对进化和生命需求的新视角。为了实现这些目标，特别是整合和协同的目标，来自不同学科的科学家必须进行互动。因此，这次会议将包括活跃的基因组研究人员，如从事数据库设计、序列分析或模拟工作的测序专家和信息学专家；遗传学家开发利用基因组信息的新方法，例如用于功能分析；以及专门从事新陈代谢、染色体结构或基因调控等基因组学领域的细胞生物学家和生物化学家。这次会议的一个焦点也将是病原体的基因组。虽然最近举行了许多基因组会议，但新基因组序列的不断完成和发布，以及对这些海量信息的分析势头的发展，意味着社区仍然需要这样的会议。在过去的七年里，这次会议已经成为一个重要的年度微生物基因组学会议，并确保了其地位和质量。

This proposal is for a conference grant for the eighth Small Genomes Conference (formerly the E. coli and Small Genomes Conference) to be held September 24-28, 2000, at the conference center in Lake Arrowhead, California. There is great excitement over the prospect of comparing the sequences and contents of as many as 50 microbial genomes over the next year or two. Considerable integration of different aspects of microbiology will undoubtedly take place, including new perspectives on evolution and the requirements for life. To acheive these goals, particularly of integration and synergy, scientists from diverse disciplines must interact. Thus, this conference will include active genome researchers, such as sequencing experts and informatics specialists working in database design, sequence analysis, or simulation; geneticists developing new methods to take advantage of genomic information, e.g. for functional analysis; and cell biologists and biochemists who have specialized in areas now ripe for genomics such as metabolism, chromosome structure, or gene regulation. One focus of this conference will also be on genomes of pathogens. While there have been a number of recent genome conferences, continuing completion and release of new genome sequences and developing momentum for analysis of this huge amount of information means the community has continued need of such conferences. This meeting has become established as a major annual microbial genomics conference during the last seven years and has assured status and quality.