SYMPOSIUM ON BIOLOGICAL REACTIVE INTERMEDIATES

生物反应中间体研讨会

• 批准号: 6199590
• 负责人: ROBERT SNYDER
• 金额: $ 0.8万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6199590
• 关键词: chemical carcinogen; free radical oxygen; meeting /conference /symposium; travel

The mechanisms by which chemicals cause their toxic or carcinogenic effects frequently involve the formation of electrophiles or free radicals, including reactive oxygen species. They often covalently bind to cellular macromolecules or cause other forms of damage which may eventually lead to cell and organ toxicity or the initiation of cancer, The International Symposium on Biological Reactive Intermediates, which began in 1975 and has been presented at five year intervals since, will next assemble at the Universite Rene Descartes, in Paris on July 16-20,2000, under the local chairmanship of Prof. Patrick Dansette. The name of the symposium will be The Sixth International Symposium on Biological Reactive Intermediates and the name of the published proceedings will be: Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to, and Prevention of Environmental Diseases. The program has been generated by an international program committee chaired by Prof. Terrence Monks, Univ. of Texas, Austin, and will feature 72 invited presentations from the USA and Europe. Highlights of the program will include a keynote presentation by Prof. Sten Orrenius of the Karolinska Institute, Stockholm and a closing lecture by Prof. F. Peter Guengerich, Vanderbilt Univ., Nashville. US members of the international organizing committee include Prof. D.J. Jollow, Medical Univ. of South Carolina, Charleston, Prof. I.G, Sipes, Univ. of Arizona, Tucson, and R. Snyder, Rutgers Univ., Piscataway. The total cost of the meeting is estimated at $235,000, of which this proposal requests $10,000 to help support the participation of 10 US speakers at $1,000/speaker.

化学品产生毒性或致癌作用的机制通常涉及亲电体或自由基的形成，包括活性氧。它们通常共价结合于细胞大分子或引起其它形式的损伤，这些损伤可能最终导致细胞和器官毒性或引发癌症。生物反应性中间体国际研讨会于1975年开始，此后每隔五年举行一次，下一次将于2000年7月16- 20日在巴黎的勒内·笛卡尔大学举行，由当地的帕特里克·丹塞特教授担任主席。研讨会的名称将是第六届生物反应中间体国际研讨会，出版的会议记录的名称将是：生物反应中间体VI：环境疾病易感性和预防的化学和生物机制。该计划由德克萨斯大学奥斯汀分校的Terrence Monks教授主持的国际计划委员会产生，将邀请来自美国和欧洲的72个演讲。研讨会的重点包括由斯德哥尔摩卡罗林斯卡学院的Sten Orrenius教授作主题演讲，以及由F. Peter Guengerich，范德比尔特大学，纳什维尔。国际组织委员会的美国成员包括南卡罗来纳州、查尔斯顿医科大学的D. J. Jollow教授、亚利桑那大学图森分校的Sipes教授和R.斯奈德，罗格斯大学，皮斯卡特维。会议的总费用估计为235，000美元，本提案要求提供10，000美元，以帮助支持10名美国发言者参加会议，每位发言者1，000美元。