SYMPOSIUM ON BIOLOGICAL REACTIVE INTERMEDIATES

化学物质产生毒性或致癌作用的机制通常涉及亲电试剂或自由基的形成，包括活性氧。它们经常与细胞大分子共价结合或引起其他形式的损害，最终可能导致细胞和器官毒性或引发癌症。生物活性中间体国际研讨会始于1975年，此后每五年举行一次，下一次会议将于2000年7月16日至20日在巴黎的勒内·笛卡尔大学举行，由当地的帕特里克·丹塞特教授担任主席。研讨会的名称将是第六届生物反应性中间体国际研讨会，发表的会议记录的名称将是：生物反应性中间体VI：环境疾病易感性和预防的化学和生物机制。该项目由德克萨斯大学奥斯汀分校的Terrence Monks教授担任主席的国际项目委员会制定，将邀请来自美国和欧洲的72位嘉宾发表演讲。该计划的亮点将包括斯德哥尔摩卡罗林斯卡研究所的Sten Orrenius教授的主题演讲和纳什维尔范德比尔特大学的F. Peter Guengerich教授的闭幕演讲。国际组委会的美国成员包括查尔斯顿南卡罗来纳医科大学的D.J. Jollow教授、图森亚利桑那大学的i.g. Sipes教授和皮斯卡塔威罗格斯大学的R. Snyder教授。会议的总费用估计为235 000美元，本提案要求其中10 000美元帮助支助10名美国发言者的参加，每名发言者1 000美元。

The mechanisms by which chemicals cause their toxic or carcinogenic effects frequently involve the formation of electrophiles or free radicals, including reactive oxygen species. They often covalently bind to cellular macromolecules or cause other forms of damage which may eventually lead to cell and organ toxicity or the initiation of cancer, The International Symposium on Biological Reactive Intermediates, which began in 1975 and has been presented at five year intervals since, will next assemble at the Universite Rene Descartes, in Paris on July 16-20,2000, under the local chairmanship of Prof. Patrick Dansette. The name of the symposium will be The Sixth International Symposium on Biological Reactive Intermediates and the name of the published proceedings will be: Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to, and Prevention of Environmental Diseases. The program has been generated by an international program committee chaired by Prof. Terrence Monks, Univ. of Texas, Austin, and will feature 72 invited presentations from the USA and Europe. Highlights of the program will include a keynote presentation by Prof. Sten Orrenius of the Karolinska Institute, Stockholm and a closing lecture by Prof. F. Peter Guengerich, Vanderbilt Univ., Nashville. US members of the international organizing committee include Prof. D.J. Jollow, Medical Univ. of South Carolina, Charleston, Prof. I.G, Sipes, Univ. of Arizona, Tucson, and R. Snyder, Rutgers Univ., Piscataway. The total cost of the meeting is estimated at $235,000, of which this proposal requests $10,000 to help support the participation of 10 US speakers at $1,000/speaker.