FOURTH INTERNATIONAL SYMPOSIUM ON BIOLOGICAL REACTIVE

第四届生物反应国际研讨会

• 批准号: 3434801
• 负责人: ROBERT SNYDER
• 金额: $ 1万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434801
• 关键词: adduct; alkylating agents; alkylation; cell cell interaction; chemical reaction; covalent bond; travel

The object of this proposal is to solicit funds to help support an international conference entitled THE FOURTH INTERNATIONAL SYMPOSIUM ON BIOLOGICAL REACTIVE INTERMEDIATES: MOLECULAR AND CELLULAR EFFECTS. The dates of the proposed meeting is January 14- 19, 1990, and the site will be Tucson, Arizona. The funds will be used to support travel and maintenance of both foreign and American speakers and chairpeople to Tucson where they will partake in presentations and discussions on the current state of our understanding of reactive intermediates, the chemistry of reactive species and covalent binding, DNA adduct formation and repair, immunotoxicology, oxygen, mycotoxins, pyrollizidine alkaloids, nitrosamines, hepatic and non-hepatic toxicity, and human disease related to reactive metabolites. Emphasis will be placed on the role of molecular targets (protein and DNA), and on the importance of cell-cell interactions in the development of tissue lesions. The program will include a series of invited speakers and several sessions at which volunteer presentations can be made in the form of poster sessions.

这项建议的目的是筹集资金，以帮助支持一个 第四国际国际会议 生物活性中间体学术讨论会：分子和 细胞效应。 建议的会议日期是1月14日- 1990年9月19日，地点将是亚利桑那州图森市。 这笔资金将 用于支持外国和美国的旅行和维护 发言人和主席前往图森， 介绍和讨论我们的 了解反应性中间体，反应性中间体的化学 物种和共价结合，DNA加合物的形成和修复， 免疫毒理学，氧气，霉菌毒素，吡咯里西啶生物碱， 亚硝胺、肝毒性和非肝毒性以及人类疾病 与活性代谢物有关。 重点将放在 分子靶点（蛋白质和DNA）的作用，以及 在组织病变的发展中细胞间的相互作用。 该计划将包括一系列受邀演讲者和几个 志愿者可以在会议上提出的形式 海报会议。