HSP 70 GENE EXPRESSION IN SCID MOUSE BRAIN

描述：（改编自申请人摘要）主要研究者 想要研究SCID突变是否会影响 热休克蛋白（hsp 70，hsc 70，grp 78）mRNA在小脑的表达 和皮层的组织损伤。她的理由是， 使用SCID小鼠的另一个缺点是，SCID小鼠是免疫缺陷的， 分化的B-或T-细胞也不加工II类组织分子。hsp 70是 位于HLA类区域，目前尚不清楚SCID突变（a 位于小鼠上的DNA依赖性蛋白激酶亚基突变 染色体16）将改变Hsp 70表达。

DESCRIPTION: (adapted from applicant's abstract) The principal investigator wants to investigate the question whether the SCID mutation affects the expression of heat shock proteins (hsp70, hsc70, grp78) mRNA in the cerebellum and cortex following heat-induced transient hyperthermia. Her rationale for using SCID mice is that SCID mice are immunodeficient and cannot produce differentiated B- or T-cell nor process Class II histomolecules. Hsp70 is located in the HLA class region and it is unknown whether the SCID mutation (a mutation in the DNA-dependent protein kinase subunit located on mouse chromosome 16) will alter the Hsp70 expression.