HSP 70 GENE EXPRESSION IN SCID MOUSE BRAIN
HSP 70 GENE EXPRESSION IN SCID MOUSE BRAIN
SCID 小鼠脑中的 HSP 70 基因表达
批准号：
6024597
负责人：
E K MILLER
金额：
$9.8万
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-05-01 至 2003-08-31
中文摘要
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英文摘要
DESCRIPTION: (adapted from applicant's abstract) The principal investigator
wants to investigate the question whether the SCID mutation affects the
expression of heat shock proteins (hsp70, hsc70, grp78) mRNA in the cerebellum
and cortex following heat-induced transient hyperthermia. Her rationale for
using SCID mice is that SCID mice are immunodeficient and cannot produce
differentiated B- or T-cell nor process Class II histomolecules. Hsp70 is
located in the HLA class region and it is unknown whether the SCID mutation (a
mutation in the DNA-dependent protein kinase subunit located on mouse
chromosome 16) will alter the Hsp70 expression.
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