Control of movements by the cerebellum
小脑对运动的控制
基本信息
- 批准号:10842088
- 负责人:
- 金额:$ 6.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-15 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AdolescenceAnimalsAwardBehavioralBiomedical EngineeringCallithrixCell NucleusCellsCerebellar DiseasesCerebellumChildhoodDisease modelEligibility DeterminationHealthLinkModelingMovementNeuronsPurkinje CellsResearchResearch Project GrantsTechnologyTestingawakeeconomic disparityembryonic stem cellgraduate studentmedical schoolsnonhuman primateprogramsundergraduate student
项目摘要
This is a request for a Administra�ve Supplement to Promote Diversity in Health-Related Research for
the currently ac�ve award 1R37NS128416 to support Alden Naeem, a first-year graduate student in the
Biomedical Engineering Program at the Johns Hopkins School of Medicine. Her eligibility for the diversity
supplement is based on economic disadvantages that she endured throughout her childhood,
adolescence, and undergraduate years. The research project that we propose for Alden Naeem is to
produce a model of cerebellar disease in a non-human primate, and then use the model to quan�fy
ac�vi�es of cells in the model-diseased cerebellum in awake behaving animals. If successful, this will
result in a first-ever model of episodic cerebellar disease in a non-human primate.
The approach that we will employ is to use chemogene�c technology to transiently, and reversibly,
manipulate the ac�vity of Purkinje cells in the cerebellum of marmosets. A sub aim is to compare the
ac�vi�es of cells in the cerebellum before and a�er Purkinje cell silencing. Importantly, we will be able to
do this comparison in the same neuron because the effects of the chemogene�c silencing are short
lived. By recording the ac�vi�es of neurons in the cerebellum when the P-cells are silenced, we will be
able to test for a causal link between modula�on of spike rates in the P-cells and their downstream
nucleus neurons, and behavioral changes such as endpoint accuracy of movements.
这是一份行政补充申请,旨在促进健康相关研究的多样性
目前正在进行的奖项 1R37NS128416 用于支持奥尔登·纳伊姆 (Alden Naeem),他是该校一年级研究生
约翰霍普金斯大学医学院的生物医学工程项目。她的多元化资格
补助金是基于她整个童年时期所承受的经济困难,
青春期、本科阶段。我们为 Alden Naeem 提出的研究项目是
在非人类灵长类动物中建立小脑疾病模型,然后使用该模型来量化
清醒行为动物模型患病小脑细胞的活动。如果成功的话,这将
首次在非人类灵长类动物中建立了阵发性小脑疾病模型。
我们将采用的方法是使用化学基因技术来瞬时且可逆地
操纵狨猴小脑中浦肯野细胞的活动。一个次要目标是比较
浦肯野细胞沉默前后小脑细胞的活动。重要的是,我们将能够
在同一神经元中进行此比较,因为化学沉默的影响很短
住过。通过记录 P 细胞沉默时小脑神经元的活动,我们将
能够测试 P 细胞及其下游尖峰速率调节之间的因果关系
核神经元和行为变化,例如运动的终点准确性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
REZA SHADMEHR其他文献
REZA SHADMEHR的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('REZA SHADMEHR', 18)}}的其他基金
A new theory of population coding in the cerebellum
小脑群体编码的新理论
- 批准号:
10005617 - 财政年份:2020
- 资助金额:
$ 6.6万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 6.6万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 6.6万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 6.6万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 6.6万 - 项目类别:
Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
- 批准号:
2889694 - 财政年份:2023
- 资助金额:
$ 6.6万 - 项目类别:
Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 6.6万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 6.6万 - 项目类别:
Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 6.6万 - 项目类别:
Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 6.6万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 6.6万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)