6TH RESEARCH CONFERENCE ON THROMBOLYSIS

本申请是为将于2000年2月6日至11日在加利福尼亚州文图拉的文图拉假日酒店举行的第六届戈登溶栓研究会议提供部分支持。这一国际会议自1990年以来每两年举行一次，深入讨论了溶栓领域最令人兴奋和最新的发展，以及纤溶蛋白在血管生成、肿瘤进展和神经生物学中的作用。本课程将涵盖基础科学和临床蛋白质开发方面的新进展。重点将放在从蛋白质结构中学习的新概念，即纤溶系统与整合素功能、神经元功能、动脉粥样硬化、血管生成和基质生物学之间的新出现的关系。此外，还将讨论用于中风治疗的新开发的临床药物。计划举行9场会议，内容包括：1.蛇毒结构和功能的进展2.纤溶和基质生物学3.纤溶受体：在细胞功能中的作用4.血管生成和血管抑素5.纤溶系统在肿瘤进展中的作用6.金属蛋白酶、动脉粥样硬化和纤溶酶系统7.最新的主题和精选海报的介绍8.神经生物学和纤溶蛋白9.治疗中风的新治疗蛋白这次会议将是整合溶栓/纤溶研究领域新知识的主要载体。目标是让每个参与者对这一迅速扩大的领域的基本生物过程和临床进展有一个全面的、最先进的了解。会议将包括妇女和少数群体作为会议领导人和发言者。将尽一切努力让博士后研究员和研究生参加讨论、下午的海报会议，并在适当的情况下作为发言者。作为会议主席，斯特里克兰博士将尽一切努力在这次会议上介绍新的和年轻的研究人员，并为他们提供在讨论中发挥领导作用的机会

This application is for partial support of the sixth Gordon Research Conference on Thrombolysis to be held at the Ventura Holiday Inn in Ventura California on February 6-11, 2000. This international conference has been held every two years since 1990, and provides in-depth discussions of the most exciting and recent developments in the field of thrombolysis and the role of fibrinolytic proteins in angiogenesis, tumor progression, and in neuronal biology. New advances in both basic science and in the development of clinical proteins will be covered. Emphasis will be placed on novel concepts learned from protein structure, in newly emerging relationships between the fibrinolytic system and integrin function, neuronal function, atherosclerosis, angiogenesis, and matrix biology. Further, newly developed clinical agents for stroke therapy will be discussed. Nine sessions are planned and will cover: 1. Advances in serpin structure and function 2. Fibrinolysis and matrix biology 3. Fibrinolytic receptors: role in cellular function 4. Angiogenesis and angiostatin 5. Role of the fibrinolytic system in tumor progression 6. Metalloproteinases, atherosclerosis, and the plasmin system 7. Late breaking topics and presentation of selected posters 8. Neurobiology and fibrinolytic proteins 9. New therapeutic proteins in the treatment of stroke This conference will be a major vehicle for the integration of new knowledge in the field of thrombolysis/fibrinolysis research. The goal is for each participant to acquire a comprehensive state-of-the-art understanding of basic biologic processes and clinical advances in this rapidly enlarging field. The conference will include women and minorities as session leaders and speakers. Every effort will be made to include post- doctoral fellows and graduate students in discussions, afternoon poster sessions, and as speakers where appropriate. As Conference Chair, Dr. Strickland will make every effort to profile new and young investigators in this conference, and to provide them with the opportunity to take a leadership role in discussions