Upgrading the CVID Biosensor Core Facility with a Biacore 8K instrument

使用 Biacore 8K 仪器升级 CVID 生物传感器核心设施

• 批准号: 10176937
• 负责人: Dudley K. Strickland
• 金额: $ 43.89万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176937
• 关键词: Attention; Biology; Biosensor; Blood Vessels; Communities; Core Facility; Disease; Experimental Designs; Funding; Genes; Genomics; Home; Inflammatory; Label; Maryland; Measures; Minor; Molecular Weight; Peer Review; Physiological; Proteomics; Publications; Reproducibility; Research; Resources; Surface Plasmon Resonance; System; Technology; Universities; biomedical resource; gene product; innovation; instrument; medical schools

Project Summary/Abstract As tremendous advances have occurred in genomic biology, gene sequencing technologies, and proteomic technologies, attention is increasingly focusing on gene products, most of which function by interacting with other gene products. A comprehensive understanding of physiological systems requires an in-depth definition of quantitative interactions between molecules. Biosensor technologies provides a powerful approach to define these interactions in label-free systems. Here we seek funds to upgrade the Biosensor Core facility in the Center of Vascular and Inflammatory Diseases (CVID) at the University of Maryland School of Medicine by the purchase of a Biacore 8K instrument. The major users of this Core have extensive expertise employing surface plasmon resonance technology with over 45 peer-reviewed publications employing the technology. The new instrument (Biacore 8K) will be integrated into the CVID Biosensor Core Facility and with the Center for Innovative Biomedical Resources (CIBR), the Administrative home for the University of Maryland School of Medicine Core facilities, thus providing the resource for our growing research community. The Biacore 8K will enhance the research of the Major users and Minor users by increasing the throughput capacity, by enhancing a more reproducible and optimized experimental design, and by increasing the sensitivity for measuring the interaction of low molecular weight molecules.

项目总结/文摘