10TH INTERNATIONAL P53 WORKSHOP

国际P53研讨会一直吸引着P53领域的科学家进行互动，讨论他们的最新科学发现，并计划合作。该系列现已在P53科学界和其他领域得到广泛认可，该领域的所有专家都参加了该系列活动。P53肿瘤抑制基因是研讨会的焦点，它与人类癌症的关系比已知的任何其他基因都要频繁。尤其是与皮肤癌和结肠癌有很强的联系，前者是紫外线照射导致P53突变，后者是化学致癌物导致P53突变。值得注意的是，每种类型的环境致癌物质都会导致p53基因的特定遗传损伤，从而使科学家能够从突变类型中识别出罪魁祸首。在细胞水平上，P53参与了细胞周期停滞、衰老和凋亡。第十届国际P53研讨会由加州大学旧金山分校主办。工作坊将於二000年四月五日至八日在美国加利福尼亚州蒙特利举行。按照字母顺序，组委会由下列人员组成：Thanos Halazonetis博士(美国维斯塔尔研究所)、Curtis Harris博士(NCI，美国)、David Lane博士(英国邓迪大学)、Arnold Levine博士(美国洛克菲勒大学)、Frank McCormick博士(美国加州大学癌症中心)、Mohe Oren博士(以色列魏兹曼研究所)、Carol Prives博士(美国哥伦比亚大学)、Varda Rotter博士(以色列魏兹曼研究所)、Thierry Soussi博士(基因毒素和基因表达调制)、Thea Tlsty博士、Ph.D.博士(法国)。主席(加州大学旧金山分校)、Karen Vousden博士(NCI，美国)和Geoffrey Wahl博士(美国索尔克研究所)。到目前为止，组委会正在筹集大量资金来支付受邀演讲者的费用。然而，第二个重要目标是确保美国研究生和博士后，包括妇女、少数族裔和残疾人获得旅行奖学金。这项提议要求美国国立卫生研究院为此类奖学金提供支持。

The International p53 Workshops have consistently attracted scientists in the p53 field to interact, discuss their latest scientific findings and plan collaborations. The series is now well-established in the p53 scientific community and beyond, and it is attended by all experts in the field. The p53 tumor suppressor, which is the focus of the Workshop, is involved in human cancer more often than any other gene known. Particularly strong connections are with skin cancer, where UV-irradiation leads to mutations in p53, and with colon carcinoma, where chemical carcinogens induce mutations in p53. Remarkably, each type of environmental carcinogen causes a specific genetic lesion in the p53 gene, allowing scientists to identify the culprit from the type of mutation. At a cellular level, p53 is involved in cell cycle arrest, senescence and apoptosis. The 10th International p53 Workshop is organized by the University of California at San Francisco, California. The Workshop will be held in Monterey, California, United States between April 5th-8th, 2000. The organizing committee consists, in alphabetical order, of: Dr. Thanos Halazonetis, (Wistar Institute, USA), Dr. Curtis Harris (NCI, USA), Dr. David Lane (U. Dundee, UK), Dr. Arnold Levine (Rockefellar U., USA), Dr. Frank McCormick (UCSF Cancer Center, USA), Dr. Moshe Oren (Weizmann Institute, Israel), Dr. Carol Prives (Columbia U., USA), Dr. Varda Rotter (Weizmann Institute, Israel), Dr. Thierry Soussi (Genotoxilogie et Modulation De I'Expression Genique, France), Dr. Thea Tlsty, Ph.D., Chair (U. of California, San Francisco, USA), Dr. Karen Vousden (NCI, USA) and Dr. Geoffrey Wahl (Salk Institute, USA). So far the organizing committee is raising significant funds to cover the expenses of invited speakers. However, a second important goal is to secure travel fellowships for U.S. graduate students and post-doss, including women, minorities and persons with disabilities. This proposal requests support from the NIH for such fellowships.