CELL CYCLING AND SIGNALING PROGRAM

细胞循环和信号转导程序

• 批准号: 7506420
• 负责人: Thea D Tlsty
• 金额: $ 6.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-25 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7506420
• 关键词: Apoptosis; Area; Basic Science; Biochemical; Budgets; Cancer Center; Cell Count; Cell Cycle; Cell Cycle Regulation; Cell Size; Cell division; Cells; Cellular biology; Cessation of life; Clinical; Collaborations; Collection; Cytoskeleton; Diagnosis; Differentiation and Growth; Disease; Endopeptidases; Ensure; Epigenetic Process; Eukaryotic Cell; Fostering; Functional disorder; Gene Expression; Genetic; Genetic Materials; Genetic Research; Goals; Growth; Human; Malignant Neoplasms; Metabolism; Molecular; Mutation; Neoplasm Metastasis; Neoplasms; Nuclear; Oncogene Proteins; Organ; Organism; Peer Review; Peptide Hydrolases; Physiological; Play; Positioning Attribute; Preventive; Process; Program Development; Publications; Purpose; Range; Regulation; Research; Role; Series; Signal Pathway; Signal Transduction; Site; Stem cells; Stress; Stromal Cells; Therapeutic; Therapeutic Intervention; Tissues; Translating; Tumor Biology; Tumor Suppressor Proteins; Whole Organism; angiogenesis; base; cancer prevention; cancer risk; cancer stem cell; cancer type; carcinogenesis; cell growth; cell motility; daughter cell; design; disorder prevention; falls; member; neoplastic cell; outcome forecast; practical application; programs; research and development; response; segregation; senescence; tumor

The Cell Cycling and Signaling Program has continued to evolve and has now expanded to include active programs in epigenetics, stem cell biology and tumor microenvironment. This interdisciplinary Program focuses on the regulation of cell signaling and cell cycle control and how alterations in these processes modulate gene expression, cause mutations, and fuel multistep carcinogenesis. The cell cycle is the collection of biochemical networks whereby one cell gives rise to two. This entails the coordination of three fundamental programs: cell growth, cell metabolism and cell division. Cell division, the increase in cell number, encompasses the proper replication and segregation of the genetic material to two daughter cells. Cell growth, the increase in cell mass and components, must be coordinated with division to ensure proper cell size, function, and position. Superimposed on both of these fundamental programs is the differentiated status of the cell, ranging from stem cell to terminal differentiation. Program Members study regulated entry into the cell cycle, which include proper molecular controls, mechanisms for ensuring the fidelity of the processes, and responses to exogenous signals for growth and differentiation. Members also study exit from the cell cycle of both the reversible kind (checkpoint control, differentiation) and the irreversible kind (senescence and death). Although core components of the cell cycle machinery are common to all eukaryotic cells, the strategy of regulation is often specific to the organism, the tissue, the cell, or the physiological/differentiated state. Multiple aspects of these processes are often controlled by nuclear organization (both genetic and epigenetic) and by signals from the extra-cellular matrix (tumor microenvironment). Observations resulting from basic research in these fundamental processes are applied to clinical questions of diagnosis, prognosis, and prevention of disease and will ultimately translate into the design of better preventive and therapeutic strategies. This Program interacts with several organ specific programs for the purpose of applying these fundamental processes to specific neoplasias. Many Members also belong to organ-specific Programs to facilitate exchange. The Program has $18,544,836 Total peer reviewed support for the last budget year. The Program has 10% intra-programmatic and 25% interprogrammatic publications.

细胞周期和信号传导程序不断发展，现在已经扩展到包括主动