LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
批准号:
6325020
负责人:
RUTH E. STARK
金额:
$2.44万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-05-01 至 2001-04-30
关键词:
antisense nucleic acid apoptosis brain neoplasms cell line enzyme inhibitors gas chromatography mass spectrometry hypoxia liposomes membrane activity membrane lipids microglia neoplastic cell neuroblastoma phagocytosis phosphatidylserines phospholipids saturated fatty acids serotonin receptor transfection
中文摘要
描述:细胞凋亡(或程序性细胞死亡)并不完全
申请人的小组已经表明,恶性肿瘤中的细胞凋亡
神经元HN 2 -5细胞系与饱和脂肪酸增加相关
增加膜刚性的酸性磷脂,
5-羟色胺1A受体(5-HT 1A-R)。 申请人假定,
膜脂组成的变化抑制了膜结合酶,
氨基磷脂移位酶(APTL),有助于定位
磷脂酰丝氨酸(PS)的内膜小叶。 的再分配
在细胞凋亡过程中,外叶的PS似乎是一个显性信号,
引发小胶质细胞对凋亡细胞的吞噬作用。 的总目标
该程序是1)了解膜脂组成的变化
发生在HN 2 -5细胞凋亡过程中,2)以确定这些变化
影响TH小胶质细胞对凋亡细胞的吞噬作用。 申请人
提出的研究要么模拟磷脂膜的变化,
以可控的方式复制它们。 他也会试图诱导一些
磷脂的变化,同时保持肿瘤的活力,
细胞 这个项目将有助于提供一个理解的一些
细胞凋亡过程中发生的细胞膜改变。
英文摘要
DESCRIPTION: Apoptosis (or programmed cell death) is not completely
understood The applicant's group has shown that apoptosis in the malignant
neuronal HN2-5 cell line is associated with an increase in saturated fatty
acid- phospholipid which increase membrane rigidity and with the expression
of serotonin 1A receptor (5-HT1A -R). The applicant postulates that a
change in membrane lipid composition inhibits such membrane-bound enzymes as
aminophospholipid translocase (APTL) which helps to localize
phosphatidylserine (PS) to the inne membrane leaflet. The redistribution of
PS to the outer leaflet during apoptosis appears to be a dominant signal to
trigger phagocytosis of apoptotic cells by microglia. The overall goals of
this program are 1) to understand wha changes in membrane lipid composition
occur in HN2-5 cells during apoptosis an 2) to determine how these changes
affect phagocytosis of apoptotic cells by th microglia. The applicant
proposes studies that will either mimic the phospholipid membrane changes or
reproduce them in a controlled manner. He wil also attempt to induce some
of the phospholipid changes while maintaining the viability of the tumor
cells. This project will help provide an understanding of some of the
membrane alterations that occur during apoptosis.
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科研奖励(0)
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负责人:RUTH E. STARK
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依托单位:
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
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项目类别:
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依托单位:
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
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批准号:6325021
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项目类别:
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财政年份:1998
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负责人:RUTH E. STARK
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项目类别:
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依托单位:
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财政年份:1989
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依托单位:
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财政年份:1989
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负责人:RUTH E. STARK
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依托单位:
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项目类别:
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负责人:RUTH E. STARK
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依托单位:
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批准号:3072532
-
项目类别:
-
资助金额:$5.49万
-
财政年份:1988
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负责人:RUTH E. STARK
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依托单位:
SPECTROSCOPIC STUDIES OF MODEL DIGESTIVE SYSTEMS
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项目类别:
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财政年份:1988
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负责人:RUTH E. STARK
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依托单位:
SPECTROSCOPIC STUDIES OF MODEL DIGESTIVE SYSTEMS
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批准号:3235461
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项目类别:
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财政年份:1988
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负责人:RUTH E. STARK
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依托单位:
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批准号:2139911
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财政年份:1988
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负责人:RUTH E. STARK
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依托单位:
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批准号:3235460
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财政年份:1988
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负责人:RUTH E. STARK
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批准号:3235459
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项目类别:
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资助金额:$7.12万
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财政年份:1988
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负责人:RUTH E. STARK
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依托单位:
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