LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
去除垂死脑肿瘤细胞时的脂质控制
基本信息
- 批准号:6325021
- 负责人:
- 金额:$ 2.44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-05-01 至 2001-04-30
- 项目状态:已结题
- 来源:
- 关键词:antisense nucleic acid apoptosis brain neoplasms cell line enzyme inhibitors gas chromatography mass spectrometry hypoxia liposomes membrane activity membrane lipids microglia neoplastic cell neuroblastoma phagocytosis phosphatidylserines phospholipids saturated fatty acids serotonin receptor transfection
项目摘要
DESCRIPTION: Apoptosis (or programmed cell death) is not completely
understood The applicant's group has shown that apoptosis in the malignant
neuronal HN2-5 cell line is associated with an increase in saturated fatty
acid- phospholipid which increase membrane rigidity and with the expression
of serotonin 1A receptor (5-HT1A -R). The applicant postulates that a
change in membrane lipid composition inhibits such membrane-bound enzymes as
aminophospholipid translocase (APTL) which helps to localize
phosphatidylserine (PS) to the inne membrane leaflet. The redistribution of
PS to the outer leaflet during apoptosis appears to be a dominant signal to
trigger phagocytosis of apoptotic cells by microglia. The overall goals of
this program are 1) to understand wha changes in membrane lipid composition
occur in HN2-5 cells during apoptosis an 2) to determine how these changes
affect phagocytosis of apoptotic cells by th microglia. The applicant
proposes studies that will either mimic the phospholipid membrane changes or
reproduce them in a controlled manner. He wil also attempt to induce some
of the phospholipid changes while maintaining the viability of the tumor
cells. This project will help provide an understanding of some of the
membrane alterations that occur during apoptosis.
描述:细胞凋亡(或程序性细胞死亡)并不完全
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RUTH E. STARK其他文献
RUTH E. STARK的其他文献
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{{ truncateString('RUTH E. STARK', 18)}}的其他基金
Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation
FABP 介导的内源性大麻素信号传导食欲调节的分子驱动因素
- 批准号:
10683375 - 财政年份:2022
- 资助金额:
$ 2.44万 - 项目类别:
Administrative Supplement to Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation
FABP 介导的内源性大麻素信号分子驱动食欲调节的行政补充
- 批准号:
10797598 - 财政年份:2022
- 资助金额:
$ 2.44万 - 项目类别:
Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation
FABP 介导的内源性大麻素信号传导食欲调节的分子驱动因素
- 批准号:
10410168 - 财政年份:2022
- 资助金额:
$ 2.44万 - 项目类别:
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
去除垂死脑肿瘤细胞时的脂质控制
- 批准号:
6095696 - 财政年份:1998
- 资助金额:
$ 2.44万 - 项目类别:
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
去除垂死脑肿瘤细胞时的脂质控制
- 批准号:
6325020 - 财政年份:1998
- 资助金额:
$ 2.44万 - 项目类别:
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
去除垂死脑肿瘤细胞时的脂质控制
- 批准号:
6095697 - 财政年份:1998
- 资助金额:
$ 2.44万 - 项目类别:
LIPID CONTROL IN THE REMOVAL OF DYING BRAIN TUMOR CELLS
去除垂死脑肿瘤细胞时的脂质控制
- 批准号:
2611440 - 财政年份:1998
- 资助金额:
$ 2.44万 - 项目类别:
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