RESPIRATORY CARCINOGENESIS BY CHEMICAL AND PHYSICAL FACTORS

继续进行组织学研究，以确定 矽肺肺病变伴有 肺泡II型上皮增生与肺 癌对300例尸检病例进行了试点研究， 来自德国萨克森地区的大量铀矿工人， 暴露在二氧化硅和辐射下的地方该人群 包括15,000多例矽肺和5,000例肺癌， 其接触史和尸检记录可供查阅， 90%的案件。在这项研究中，与NIOSH合作设计， NCI流行病学家，四名病理学家独立分类 上皮增生性病变和肺癌。 尸检病例的选择基于分层、分层 抽样方案，用于对不同接触水平的病例进行抽样 氡气和石英尘病理学家之间的一致性水平 小细胞未分化型占90.6%~ 94.3 鳞癌87.8%~ 92.9%，鳞癌87.7%~ 95.1%， 腺癌85.4%~ 96.5%。数据将 将进一步分析和检查其他材料。

Histopathology studies were continued in order to identify the conditions under which silicotic lung lesions are accompanied by alveolar type II epithelial hyperplasia and associated with lung carcinomas. A pilot study of 300 autopsy cases was completed from a large population of uranium miners from the Saxony region in Germany, that received heavy exposures to silica and radiation. This population includes over 15,000 cases of silicosis and 5,000 cases of lung cancer, for which exposure histories and autopsy records are available for over 90% of cases. In this study, designed in collaboration with NIOSH and NCI epidemiologists, four pathologists independently classified epithelial proliferative lesions and lung cancers by histologic type. The autopsy cases were selected based on a hierarchical, stratified sampling scheme designed to sample cases with varying levels of exposure to radon and quartz dust. The levels of agreement between pathologist pairs ranged from 90.6% to 94.3% for small cell undifferentiated carcinoma, 87.8%-92.9% for squamous cell, 87.7%-95.1% for adenocarcinoma, and 85.4%-96.5% for large cell carcinoma. The data will be further analyzed and additional materials will be examined.