ORAL CARCINOGENESIS

头颈部鳞状细胞癌（HNSCC）是第六大 在发达国家常见的癌症，并可能与 烟草中存在的化学致癌物，以及不太清楚的致癌物质， 病毒 尽管它的频率很高，但人们对它的分子结构知之甚少。 导致疾病发生和进展的事件。 删除 p53或突变是良性和恶性肿瘤的特征， 广泛的组织类型，包括口腔粘膜。尽管几 研究表明，HNSCC中的p53畸变， 在该系统中，这种突变对肿瘤发展的贡献仍然存在 未经证实因此，我们的研究集中在确定可能的 HNSCC衍生的p53突变体在肿瘤建立和进展中的作用， 使用p53功能的体内测定。

Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common cancer in the developed world, and is likely associated with chemical carcinogens present in tobacco, and, less clearly, with oncogenic viruses. In spite of its frequency, little is known about the molecular events which contribute to disease initiation and progression. Deletion or mutation of p53 characterizes benign and malignant neoplasms from a broad spectrum of tissues types, including oral mucosa. Although several studies have demonstrated p53 aberrations in HNSCC, the functional contribution of such mutations to tumor development in this system remains unproven. Our studies, therefore, have focussed on determining the likely role of HNSCC-derived p53 mutants on tumor establishment and progression, using in vivo assays of p53 function.