TUMOR SUPPRESSOR GENE AT 13Q21 IN PROSTATE CANCER

2021 年第 13 季度前列腺癌中的肿瘤抑制基因

• 批准号: 6191110
• 负责人: JIN-TANG DONG
• 金额: $ 24.12万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-18 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6191110
• 关键词: apoptosis; artificial chromosomes; athymic mouse; carcinogenesis; cell line; cell proliferation; clinical research; complementary DNA; gene deletion mutation; genetic polymorphism; homozygote; human subject; loss of heterozygosity; male; neoplasm /cancer genetics; polymerase chain reaction; prostate neoplasms; sequence tagged sites; single strand conformation polymorphism; tumor suppressor genes

DESCRIPTION (Adapted from investigator's abstract): Prostate cancer has a complex pathogenesis in which many men develop early stage 'benign' cancers, and a much smaller but substantial number develop aggressive cancers that metastasize and cause premature death. The PI has identified a region on chromosome 13q21 which appears to contain a gene whose alteration contributes to the aggressive behavior of prostate cancer. This region is subject to LOH and homozygous deletion in aggressive prostate cancers and cell lines. The current minimal region contains at least three genes which are expressed in normal prostate and low-grade tumors, but not aggressive cancers. The PI now proposes to define the smallest region of deletions that contains the 13q21 gene; to identify the 13q21 tumor suppressor gene (TSG) through expression and mutation analyses; to express the gene in cancer cell lines to examine effects on growth and metastasis; and examine in greater detail how often LOH and homozygous deletion affect the gene, the expression of the gene in prostate cancer, and clinical and pathologic correlations including prognostic significance.

描述（改编自研究者摘要）：前列腺癌有一个