TUMOR SUPPRESSOR GENE AT 13Q21 IN PROSTATE CANCER

2021 年第 13 季度前列腺癌中的肿瘤抑制基因

基本信息

  • 批准号:
    6191110
  • 负责人:
  • 金额:
    $ 24.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-08-18 至 2005-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Adapted from investigator's abstract): Prostate cancer has a complex pathogenesis in which many men develop early stage 'benign' cancers, and a much smaller but substantial number develop aggressive cancers that metastasize and cause premature death. The PI has identified a region on chromosome 13q21 which appears to contain a gene whose alteration contributes to the aggressive behavior of prostate cancer. This region is subject to LOH and homozygous deletion in aggressive prostate cancers and cell lines. The current minimal region contains at least three genes which are expressed in normal prostate and low-grade tumors, but not aggressive cancers. The PI now proposes to define the smallest region of deletions that contains the 13q21 gene; to identify the 13q21 tumor suppressor gene (TSG) through expression and mutation analyses; to express the gene in cancer cell lines to examine effects on growth and metastasis; and examine in greater detail how often LOH and homozygous deletion affect the gene, the expression of the gene in prostate cancer, and clinical and pathologic correlations including prognostic significance.
描述(改编自研究者摘要):前列腺癌有一个

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JIN-TANG DONG其他文献

JIN-TANG DONG的其他文献

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{{ truncateString('JIN-TANG DONG', 18)}}的其他基金

Bidirectional role of KLF5 in prostatic epithelial homeostasis and tumorigenesis
KLF5 在前列腺上皮稳态和肿瘤发生中的双向作用
  • 批准号:
    8842945
  • 财政年份:
    2013
  • 资助金额:
    $ 24.12万
  • 项目类别:
Bidirectional role of KLF5 in prostatic epithelial homeostasis and tumorigenesis
KLF5 在前列腺上皮稳态和肿瘤发生中的双向作用
  • 批准号:
    9246467
  • 财政年份:
    2013
  • 资助金额:
    $ 24.12万
  • 项目类别:
Bidirectional role of KLF5 in prostatic epithelial homeostasis and tumorigenesis
KLF5 在前列腺上皮稳态和肿瘤发生中的双向作用
  • 批准号:
    8508407
  • 财政年份:
    2013
  • 资助金额:
    $ 24.12万
  • 项目类别:
DEVELOPMENTAL RESEARCH PROGRAM
发展研究计划
  • 批准号:
    7300644
  • 财政年份:
    2007
  • 资助金额:
    $ 24.12万
  • 项目类别:
Role of ATBF1 inactivation in the development and progression of prostate cancer
ATBF1失活在前列腺癌发生和进展中的作用
  • 批准号:
    7597198
  • 财政年份:
    2006
  • 资助金额:
    $ 24.12万
  • 项目类别:
Role of ATBF1 inactivation in the development and progression of prostate cancer
ATBF1失活在前列腺癌发生和进展中的作用
  • 批准号:
    7031932
  • 财政年份:
    2006
  • 资助金额:
    $ 24.12万
  • 项目类别:
Role of ATBF1 inactivation in the development and progression of prostate cancer
ATBF1失活在前列腺癌发生和进展中的作用
  • 批准号:
    7223401
  • 财政年份:
    2006
  • 资助金额:
    $ 24.12万
  • 项目类别:
Role of ATBF1 inactivation in the development and progression of prostate cancer
ATBF1失活在前列腺癌发生和进展中的作用
  • 批准号:
    7388931
  • 财政年份:
    2006
  • 资助金额:
    $ 24.12万
  • 项目类别:
Role of ATBF1 inactivation in the development and progression of prostate cancer
ATBF1失活在前列腺癌发生和进展中的作用
  • 批准号:
    7784547
  • 财政年份:
    2006
  • 资助金额:
    $ 24.12万
  • 项目类别:
Overexpression of ubiquitin E3 ligase WWP1 as an oncogenic factor in the prostate
泛素 E3 连接酶 WWP1 过度表达作为前列腺致癌因子
  • 批准号:
    7094733
  • 财政年份:
    2000
  • 资助金额:
    $ 24.12万
  • 项目类别:

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