ACUPUNCTURE AND COPING SKILLS TRAINING FOR COCAINE ABUSE

描述：（申请人摘要） 这种竞争性的更新要求资金继续我们的研究调查 耳针治疗可卡因成瘾上一 在拨款期内，我们进行了三项临床研究，共有211名病人参加。每个 一项研究将耳针与两种对照条件进行了比较， 使用耳廓螺旋中的位点的插入控制，和松弛组- 在各种条件下，有或没有广泛使用的心理社会学 治疗（应对技能培训- CST）以及财政奖励， 出席情况.研究结果支持针灸的疗效， 与科技委合作，不提供财政奖励。但是这些研究 并不是为了明确地研究针灸和 和CST，或确定针灸是否比CST更有效 单独交付。这项研究建立在我们以前的研究基础上， 研究两种广泛使用的治疗方法及其相互作用-针灸和 CST -在每种治疗均由物质提供的临床背景下 滥用辅导员，采用研究设计符合需要， 研究结果的临床实践，以及其中每一个相对成本 治疗也被考虑。我们建议进行“第三阶段”临床试验， 200名可卡因滥用美沙酮维持治疗的患者， 标准美沙酮维持治疗，将被随机分配到4 治疗条件，每12周的持续时间，在一个2（针灸/不 针灸）2（每周应对技能训练组/无应对技能 训练）析因设计。四组分别为：（a）单纯针刺组（ACU）; (b)仅进行应对技能训练（CST）;（c）针灸加应对技能 培训（ACU+CST）;（d）仅使用标准美沙酮维持治疗（MM）。在第二 研究阶段，以探索这些治疗的有效性 在预防复发方面，在12周试验中开始禁欲的患者 将被邀请继续接受6个月的指定治疗。两 临床疗效、成本以及治疗/患者匹配变量将 接受检查。

DESCRIPTION: (Applicant's Abstract) This competing renewal requests funds to continue our research investigating auricular acupuncture as a treatment for cocaine addiction. In the previous grant period we conducted three clinical studies enrolling 211 patients. Each study compared auricular acupuncture to two control conditions - a needle insertion control using sites in the auricle helix, and a relaxation group - under a variety of conditions, with and without a widely used psychosocial treatment (Coping Skills Training - CST) as well as financial incentives for attendance. Findings supported the efficacy of acupuncture when provided in conjunction with CST and without financial incentives. However, these studies were not designed to definitively examine the interaction between acupuncture and CST, or to determine whether acupuncture is more effective than CST delivered alone. The proposed study builds upon our previous research and will investigate two widely used treatments and their interactions - acupuncture and CST - in a clinical context in which each treatment is provided by substance abuse counselors, employing a research design consistent with the need to bring research findings to clinical practice, and in which relative cost of each treatment is also considered. We propose to conduct a "Phase III" clinical trial in which 200 cocaine-abusing methadone maintained patients, all receiving standard methadone maintenance treatment, will be randomly assigned to 4 treatment conditions, each of 12 weeks duration, in a 2 (acupuncture/no acupuncture) by 2 (weekly coping skills training group/no coping skills training) factorial design. The four groups are: (a) acupuncture only (ACU); (b) coping skills training only (CST); (c) acupuncture plus coping skills training (ACU+CST); (d) standard methadone maintenance only (MM). In a second phase of the study, in order to explore the effectiveness of these treatments in preventing relapse, patients who initiate abstinence in the 12-week trial will be invited to continue their assigned treatment for 6 months. Both clinical efficacy, cost, as well as treatment/patient matching variables, will be examined.