Diabetic cardiomyopathy: defining new mechanisms of cardiomyocyte injury and loss

糖尿病心肌病：定义心肌细胞损伤和丢失的新机制

• 批准号: nhmrc : 1027865
• 负责人: Prof Leanne Delbridge
• 金额: $ 40.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/diabetic-cardiomyopathy-defining-injury-loss/110601
• 关键词: Diabetic; cardiomyopathy; defining; new; mechanisms

The heart is recognized as an important casualty organ in the progression of diabetes – both type 1 and type 2. We have new evidence that in diabetic and pre-diabetic hearts there is excess breakdown of heart cell structure in order to scavenge metabolic fuel, and that this scavenging can lead to heart cell death. Our goal is to identify ways in which the heart may be protected against this pathology and to identify new molecular targets for treatment of diabetic hearts.

心脏被认为是糖尿病进展中的重要损伤器官-1型和2型。我们有新的证据表明，在糖尿病和糖尿病前期的心脏中，心脏细胞结构过度分解，以清除代谢燃料，这种清除可能导致心脏细胞死亡。我们的目标是确定心脏可能被保护免受这种病理的方法，并确定治疗糖尿病心脏的新分子靶点。