Linking early heart growth stress and adult cardiopathology: a new role for autophagy

将早期心脏生长应激与成人心脏病理学联系起来：自噬的新作用

• 批准号: nhmrc : 628643
• 负责人: Prof Leanne Delbridge
• 金额: $ 34.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/linking-early-heart-role-autophagy/97385
• 关键词: Linking; early; heart; growth; stress

An enlarged heart at maturity is a major risk factor. The goal of this project is to understand how cardiac growth abnormality in the neonate contributes to adult growth pathology. We have recently discovered that a type of stress-triggered cell death (autophagy) is increased in rodent neonatal hearts which later become enlarged, and that this cell death is regulated by the hormone angiotensin II. We will study the mechanisms involved to identify intervention opportunities to normalize growth.

成熟时心脏增大是一个主要的风险因素。这个项目的目标是了解新生儿心脏发育异常是如何导致成人发育病理的。我们最近发现，在啮齿动物新生心脏中，一种由应激引发的细胞死亡(自噬)增加，后来心脏变大，这种细胞死亡受激素血管紧张素II的调节。我们将研究其中涉及的机制，以确定正常生长的干预机会。