RISK MARKERS FOR DEMENTIA AFTER STROKE

中风后痴呆症的风险标志

• 批准号: 6088859
• 负责人: PHILIP B GORELICK
• 金额: $ 54.11万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6088859
• 关键词: Alzheimer's disease; bioimaging /biomedical imaging; biomarker; brain disorder diagnosis; cerebral ischemia /hypoxia; clinical research; dementia; diagnosis design /evaluation; human subject; magnetic resonance imaging; neuropathology; stroke

DESCRIPTION (Adapted from Applicant's Abstract): Dementia and cognitive impairment associated with stroke are an important but enigmatic public health problem. As many stroke patients are elderly, concomitant pathophysiologic mechanisms may play a role in the genesis of their dementia. Now, novel quantitative MRI imaging technology is available as a potentially powerful in vivo research tool that may identify factors that contribute to dementia and cognitive impairment in patients with stroke. The major aim of this proposal is to identify risk markers such as hippocampal and entorhinal cortex volume, white matter dysfunction, stroke volume, and generalized brain volume by quantitative MRI technology that may contribute to dementia and cognitive impairment in stroke patients. The applicants propose to use a new technology of quantitative MRI analysis, diffusion tensor scanning, to study diseased white matter of the brain. The proposed analysis will take into account MRI and other factors that may be important in the genesis of dementia after stroke by case-control methodology among ischemic stroke patients who do or do not develop dementia. The applicants propose to study the contribution of MRI markers of Alzheimer's disease (AD) in stroke patients. In those stroke patients who do not show quantitative MRI markers for AD, it may be possible to begin to define 'vascular dementia.' The findings will be validated by neuropathologic correlation among patients who come to autopsy. By defining the role of quantitative MRI analysis in dementia patients after stroke, the applicants propose to clarify the concept of 'vascular dementia.' They state that refinement in our knowledge of mechanisms and causes for dementia in stroke patients may lead to an improvement in prevention and treatment strategies.

描述（改编自申请人的摘要）：痴呆和认知障碍 与中风相关损伤是重要但神秘的公共卫生 问题.由于许多中风患者是老年人， 机制可能在他们的痴呆症的发生中起作用。现在，小说 定量MRI成像技术可作为一种潜在的强大的 体内研究工具，可以确定导致痴呆症的因素， 脑卒中患者的认知障碍。这项建议的主要目的是 为了识别诸如海马和内嗅皮质体积的风险标记， 白色功能障碍、每搏输出量和广义脑容量， 定量MRI技术，可能有助于痴呆症和认知 中风患者的损伤。申请人建议使用一种新技术 定量MRI分析，扩散张量扫描，研究病变 脑中的白色物质。拟议的分析将考虑MRI和 其他可能在中风后痴呆发生中起重要作用的因素 缺血性卒中患者中的病例对照方法， 患上痴呆症申请人建议研究MRI的贡献 阿尔茨海默病（AD）的标志物在中风患者。在这些中风 没有显示AD的定量MRI标记物的患者， 开始定义“血管性痴呆。“调查结果将得到验证， 神经病理学相关性。通过定义 定量MRI分析在卒中后痴呆患者中的作用， 申请人提出澄清“血管性痴呆”的概念。他们说， 我们对痴呆症的机制和原因的认识的完善， 中风患者可能会导致预防和治疗的改善 战略布局