RISK MARKERS FOR DEMENTIA AFTER STROKE

中风后痴呆症的风险标志

• 批准号: 6372468
• 负责人: PHILIP B GORELICK
• 金额: $ 58.34万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6372468
• 关键词: Alzheimer's disease; bioimaging /biomedical imaging; biomarker; brain disorder diagnosis; cerebral ischemia /hypoxia; clinical research; dementia; diagnosis design /evaluation; human subject; magnetic resonance imaging; neuropathology; stroke

DESCRIPTION (Adapted from Applicant's Abstract): Dementia and cognitive impairment associated with stroke are an important but enigmatic public health problem. As many stroke patients are elderly, concomitant pathophysiologic mechanisms may play a role in the genesis of their dementia. Now, novel quantitative MRI imaging technology is available as a potentially powerful in vivo research tool that may identify factors that contribute to dementia and cognitive impairment in patients with stroke. The major aim of this proposal is to identify risk markers such as hippocampal and entorhinal cortex volume, white matter dysfunction, stroke volume, and generalized brain volume by quantitative MRI technology that may contribute to dementia and cognitive impairment in stroke patients. The applicants propose to use a new technology of quantitative MRI analysis, diffusion tensor scanning, to study diseased white matter of the brain. The proposed analysis will take into account MRI and other factors that may be important in the genesis of dementia after stroke by case-control methodology among ischemic stroke patients who do or do not develop dementia. The applicants propose to study the contribution of MRI markers of Alzheimer's disease (AD) in stroke patients. In those stroke patients who do not show quantitative MRI markers for AD, it may be possible to begin to define 'vascular dementia.' The findings will be validated by neuropathologic correlation among patients who come to autopsy. By defining the role of quantitative MRI analysis in dementia patients after stroke, the applicants propose to clarify the concept of 'vascular dementia.' They state that refinement in our knowledge of mechanisms and causes for dementia in stroke patients may lead to an improvement in prevention and treatment strategies.

描述（改编自申请人的摘要）：痴呆症和认知 与中风相关的损害是一个重要但神秘的公共卫生问题 问题。由于许多中风患者年龄较大，因此伴随病理生理学变化 机制可能在痴呆症的发生中发挥作用。现在，小说 定量 MRI 成像技术可作为一种潜在的强大技术 体内研究工具可以识别导致痴呆症的因素 中风患者的认知障碍。该提案的主要目的是 识别风险标记，例如海马和内嗅皮层体积， 白质功能障碍、每搏输出量和广义脑容量 可能导致痴呆和认知障碍的定量 MRI 技术 中风患者的损伤。申请人提议使用一项新技术 定量 MRI 分析、扩散张量扫描来研究病变 大脑白质。拟议的分析将考虑 MRI 和 其他可能对中风后痴呆发生起重要作用的因素 接受或不接受治疗的缺血性卒中患者的病例对照方法 发展为痴呆症。申请人提议研究MRI的贡献 中风患者阿尔茨海默病（AD）的标志物。在那些中风 对于未显示 AD 定量 MRI 标记的患者，可能可以 开始定义“血管性痴呆”。研究结果将由以下机构验证 进行尸检的患者之间的神经病理学相关性。通过定义 定量 MRI 分析在中风后痴呆患者中的作用 申请人建议澄清“血管性痴呆”的概念。他们指出 我们对痴呆症机制和原因的认识不断完善 中风患者可能会改善预防和治疗 策略。