3D SONOELASTOGRAPHY IMAGING FOR PROSTATE CANCER

前列腺癌 3D 声弹性成像

• 批准号: 6168857
• 负责人: Deborah J Rubens
• 金额: $ 26.91万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168857
• 关键词: bioimaging /biomedical imaging; biopsy; clinical research; computer program /software; diagnosis quality /standard; digital imaging; elasticity; histopathology; human subject; image processing; neoplasm /cancer diagnosis; phantom model; prostate neoplasms; prostate surgery; technology /technique development; ultrasonography

Prostate Cancer, the most prevalent male cancer and second leading cause of male cancer death, is currently detected by screening PSA and physical examination and confirmed with TRUS-guided prostate biopsy. Current diagnostic sensitivity is limited by poor visualization of tumor and inadequate sampling. Our fundamental hypothesis is that sonoelastography imaging can enable the detection of prostate cancer that otherwise appears normal in conventional in-vivo US imaging. A corollary of this hypothesis is that 3D sonoelastography can demarcate and help to calculate the volume of a suspected tumor region. Sonoelastic ultrasound imaging will enable earlier prostate cancer diagnosis due to better biopsy guidance and fewer false negative biopsies. Three-dimensional tumor volume analysis will provide quantification and localization for customized treatment, including tumor boost dose in brachytherapy. We propose a three-stage research plan to develop the technology of sonoelastography to test this hypothesis: Stage 1. Equipment optimization of vibration source, frequency, signal processing, 3D rendering and analysis will be tested in Phantom and ex-vivo tissue models using a GE Logiq 700MR with specially configured software. Stage 2. Optimized parameters will be applied to fresh, whole prostatectomy specimens from patients with prostate cancer, and correlated with step-section pathology. Volumetric and morphologic parameters of sonoelastic images and rendered volumes versus specimen dimensions will also be assessed. Further adjustments will be made to hardware and software as suggested by these results. Stage 3. In-vivo scans will be performed on consenting patients screened for prostate cancer subsequently referred for radical prostatectomy and in selected control patients without prostate cancer undergoing cystoprostatectomy. Comparisons will be made with specimen scans and pathology results as in Stage II. Successful verification of these postulates will permit significant improvement in prostate cancer detection and treatment.

前列腺癌是最常见的男性癌症，也是男性癌症死亡的第二大原因，目前通过筛查 PSA 和体检来检测，并通过 TRUS 引导的前列腺活检进行确诊。 目前的诊断灵敏度受到肿瘤可视化较差和采样不足的限制。我们的基本假设是，声弹性成像可以检测出在传统体内超声成像中看似正常的前列腺癌。 这一假设的推论是 3D 声弹性成像可以标定并帮助计算可疑肿瘤区域的体积。 由于更好的活检指导和更少的假阴性活检，声弹性超声成像将能够实现前列腺癌的早期诊断。三维肿瘤体积分析将为定制治疗提供量化和定位，包括近距离放射治疗中的肿瘤增强剂量。我们提出了一个三阶段的研究计划来开发声弹性成像技术来测试这一假设： 第一阶段。振动源、频率、信号处理、3D 渲染和分析的设备优化将使用具有特殊配置软件的 GE Logiq 700MR 在 Phantom 和离体组织模型中进行测试。 第 2 阶段。优化的参数将应用于前列腺癌患者的新鲜全前列腺切除标本，并与分段病理学相关。 还将评估声弹性图像的体积和形态参数以及渲染体积与样本尺寸的关系。将根据这些结果建议对硬件和软件进行进一步的调整。 第三阶段。体内扫描将对同意接受前列腺癌筛查、随后转诊进行根治性前列腺切除术的患者以及接受膀胱前列腺切除术的未患前列腺癌的选定对照患者进行。将与第二阶段的标本扫描和病理学结果进行比较。 这些假设的成功验证将显着改善前列腺癌的检测和治疗。