3D SONOELASTOGRAPHY IMAGING FOR PROSTATE CANCER

前列腺癌 3D 声弹性成像

• 批准号: 6804403
• 负责人: Deborah J Rubens
• 金额: $ 43.62万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804403
• 关键词: aging; bioimaging /biomedical imaging; biopsy; clinical research; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; digital imaging; elasticity; histopathology; human subject; image processing; male; neoplasm /cancer diagnosis; prostate neoplasms; prostate specific antigen; three dimensional imaging /topography

DESCRIPTION (provided by applicant): Prostate Cancer, the most prevalent male cancer and second leading cause of male cancer death, is currently detected by screening PSA and physical examination and confirmed with TRUS-guided prostate biopsy. Current diagnostic sensitivity is limited by poor visualization of tumor and inadequate sampling. Our fundamental hypothesis is that sonoelastography imaging can enable the detection of prostate cancer that otherwise appears normal in conventional in-vivo US imaging. A corollary of this hypothesis is that 3D sonoelastography can demarcate and help to calculate the volume of a suspected tumor region. Sonoelastic ultrasound imaging will enable earlier prostate cancer diagnosis due to better biopsy guidance and fewer false negative biopsies. Three-dimensional tumor volume analysis will provide quantification and localization for customized treatment, including tumor boost dose in brachytherapy. Our progress to date has led to new information regarding basic elements of sonoelastography including aliasing and modal patterns, tissue frequency dependence and variable beam patterns; and the techniques of 3D image pathology fusion. Our in-vivo work has similarly identified variables of gain, frequency, source beam patterns, and attenuation, which need to be controlled. Our next phase of research will focus on the following three aims: Aim 1: Develop the (currently unknown) theoretical and experimental characterization of the frequency dependent elastic properties of the normal prostate and of the prostate with benign and malignant conditions of high prevalence. (Year 1, with later extensions) Aim 2: Refine and advance our 3D Sonoelastography systems to increase the sensitivity, linearity, spatial resolution, and vibration frequency range so as to increase the detectability of cancer. (Year 1: 25 patients) Aim 3: Apply the results of aims 1 and 2 to evaluate the clinical utility of in-vivo prostate cancer detection by sonoelastography. (Years 2-4: 90 patients)

描述（由申请人提供）：前列腺癌是最常见的男性癌症，也是男性癌症死亡的第二大原因，目前通过筛查 PSA 和体检来检测，并通过 TRUS 引导的前列腺活检进行确诊。 目前的诊断灵敏度受到肿瘤可视化较差和采样不足的限制。我们的基本假设是，声弹性成像可以检测出在传统体内超声成像中看似正常的前列腺癌。这一假设的推论是 3D 声弹性成像可以标定并帮助计算可疑肿瘤区域的体积。由于更好的活检指导和更少的假阴性活检，声弹性超声成像将能够实现前列腺癌的早期诊断。三维肿瘤体积分析将为定制治疗提供量化和定位，包括近距离放射治疗中的肿瘤增强剂量。 迄今为止，我们取得的进展已经带来了有关声弹性成像基本要素的新信息，包括混叠和模态模式、组织频率依赖性和可变波束模式；以及3D图像病理融合技术。我们的体内工作也类似地确定了需要控制的增益、频率、源波束模式和衰减的变量。我们下一阶段的研究将重点关注以下三个目标： 目标 1：开发正常前列腺和良性和恶性疾病高患病率前列腺的频率依赖性弹性特性（目前未知）的理论和实验表征。 （第一年，后来延长） 目标 2：完善和改进我们的 3D 声弹性成像系统，以提高灵敏度、线性度、空间分辨率和振动频率范围，从而提高癌症的可检测性。 （第一年：25 名患者） 目标 3：应用目标 1 和 2 的结果来评估超声弹性成像体内前列腺癌检测的临床效用。 （2-4 年：90 名患者）