3D SONOELASTOGRAPHY IMAGING FOR PROSTATE CANCER

前列腺癌 3D 声弹性成像

• 批准号: 6901837
• 负责人: Deborah J Rubens
• 金额: $ 42.65万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6901837
• 关键词: aging; bioimaging /biomedical imaging; biopsy; clinical research; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; digital imaging; elasticity; histopathology; human subject; image processing; male; neoplasm /cancer diagnosis; prostate neoplasms; prostate specific antigen; three dimensional imaging /topography

DESCRIPTION (provided by applicant): Prostate Cancer, the most prevalent male cancer and second leading cause of male cancer death, is currently detected by screening PSA and physical examination and confirmed with TRUS-guided prostate biopsy. Current diagnostic sensitivity is limited by poor visualization of tumor and inadequate sampling. Our fundamental hypothesis is that sonoelastography imaging can enable the detection of prostate cancer that otherwise appears normal in conventional in-vivo US imaging. A corollary of this hypothesis is that 3D sonoelastography can demarcate and help to calculate the volume of a suspected tumor region. Sonoelastic ultrasound imaging will enable earlier prostate cancer diagnosis due to better biopsy guidance and fewer false negative biopsies. Three-dimensional tumor volume analysis will provide quantification and localization for customized treatment, including tumor boost dose in brachytherapy. Our progress to date has led to new information regarding basic elements of sonoelastography including aliasing and modal patterns, tissue frequency dependence and variable beam patterns; and the techniques of 3D image pathology fusion. Our in-vivo work has similarly identified variables of gain, frequency, source beam patterns, and attenuation, which need to be controlled. Our next phase of research will focus on the following three aims: Aim 1: Develop the (currently unknown) theoretical and experimental characterization of the frequency dependent elastic properties of the normal prostate and of the prostate with benign and malignant conditions of high prevalence. (Year 1, with later extensions) Aim 2: Refine and advance our 3D Sonoelastography systems to increase the sensitivity, linearity, spatial resolution, and vibration frequency range so as to increase the detectability of cancer. (Year 1: 25 patients) Aim 3: Apply the results of aims 1 and 2 to evaluate the clinical utility of in-vivo prostate cancer detection by sonoelastography. (Years 2-4: 90 patients)

描述(申请人提供)：前列腺癌是最常见的男性癌症，也是男性癌症死亡的第二大原因，目前通过筛查PSA和体检发现，并经TRUS引导的前列腺活检证实。目前的诊断灵敏度受到肿瘤可视化差和采样不足的限制。我们的基本假设是，超声弹性成像可以检测到前列腺癌，否则在传统的活体US成像中看起来是正常的。这一假设的一个推论是，3D超声弹性成像可以划定并帮助计算可疑肿瘤区域的体积。由于更好的活检指导和较少的假阴性活检，超声超声成像将使前列腺癌早期诊断成为可能。三维肿瘤体积分析将为个性化治疗提供量化和定位，包括近距离放射治疗中的肿瘤增强剂量。到目前为止，我们的进展带来了关于超声弹性成像基本元素的新信息，包括混叠和模式模式、组织频率相关性和可变波束模式；以及3D图像病理融合技术。我们在体内的工作也同样确定了需要控制的增益、频率、源波束模式和衰减等变量。我们下一阶段的研究将集中在以下三个目标上： 目的1：发展(目前未知的)正常前列腺和高患病率良性和恶性前列腺的频率依赖性弹性特性的理论和实验表征。(第一年，后来的延期) 目的2：改进和改进我们的三维超声弹性成像系统，以提高灵敏度、线性度、空间分辨率和振动频率范围，从而提高癌症的检测能力。(第1年：25名病人) 目的3：应用AIMS 1和AIMS 2的结果评价超声弹性成像在体内检测前列腺癌的临床应用价值。(第2至第4年：90名病人)