PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING

描述(改编自申请者摘要)：次要卧床休息 疾病、手术或受伤往往会给老年人带来严重的后果 成人，包括身体功能减退和独立性受损。 老年人可能会失去执行日常基本活动的能力 并失去了短距离行走的能力。此外, 老年人在卧床休息一段时间后可能无法恢复功能， 导致永久丧失功能和可能的养老院安置。 研究发现，卧床休息后的康复比卧床休息更有效 完全不干预，但患者很少能恢复到以前的水平 功能。减少卧床休息时功能损失的新策略 需要制定策略来优化身体机能的恢复。一种可能 减轻功能丧失和身体衰退的策略是提供 在卧床休息一段时间之前的康复前服务。这就是我们的意图 这项研究的目的是检验康复训练的有效性， 与传统康复相比，采用动物模型卧床休息。 步行能力、肌肉功能和僵硬程度以及骨量和 力量将在幼年和年长的动物身上得到检验 模拟卧床前的康复训练。我们将对它们进行比较 对接受康复运动的幼年和老年动物的收获 模拟卧床休息后。如果初步调查结果得到证实，它将 为适当的人体研究提供支持，并为扩大 为老年人提供的适应服务既包括适应前服务，也包括 康复。

DESCRIPTION (Adapted from the Applicant's Abstract): Bed rest secondary to illness, surgery or injury often has serious consequences for the older adult, including diminished physical function and compromised independence. Older adults may lose the capacity to perform basic activities of daily living and lose their ability to ambulate short distances. In addition, older adults may not recover function following a period of bed rest, resulting in permanent loss of function and possible nursing home placement. Rehabilitation has been found to be more effective following bed rest than no intervention at all but rarely do patients regain former levels of function. New strategies to minimize loss of function during bed rest and strategies to optimize return of physical function are needed. One possible strategy to attenuate loss of function and physical decline is to provide pre-habilitation services prior to a period of bed rest. It is the intent of this study to examine the effectiveness of pre-habilitation exercises, compared to traditional rehabilitation, using an animal model of bed rest. Changes in walking ability, muscle function and stiffness, and bone mass and strength will be examined in young and old animals receiving pre-habilitation exercise before simulated bed rest. These will be compared to gains made in young and old animals receiving rehabilitation exercise after simulated bed rest. If preliminary findings are confirmed, it would provide support for appropriate human studies, and for expansion of habilitation services to older adults to include both pre-habilitation and rehabilitation.