PREHAB VS REHAB FOR REDUCING BEDREST EFFECTS WITH AGING

预康复与康复在减少因衰老而卧床的影响方面的比较

• 批准号: 6532500
• 负责人: MARYBETH none BROWN
• 金额: $ 13.94万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6532500
• 关键词: age difference; aging; biological models; bone density; bone imaging /visualization /scanning; exercise; functional ability; gait; histology; joint stiffness; laboratory rat; limb movement; medical rehabilitation related tag; muscle function; nonhuman therapy evaluation; photon absorptiometry; rehabilitation; restricted physical activity

DESCRIPTION (Adapted from the Applicant's Abstract): Bed rest secondary to illness, surgery or injury often has serious consequences for the older adult, including diminished physical function and compromised independence. Older adults may lose the capacity to perform basic activities of daily living and lose their ability to ambulate short distances. In addition, older adults may not recover function following a period of bed rest, resulting in permanent loss of function and possible nursing home placement. Rehabilitation has been found to be more effective following bed rest than no intervention at all but rarely do patients regain former levels of function. New strategies to minimize loss of function during bed rest and strategies to optimize return of physical function are needed. One possible strategy to attenuate loss of function and physical decline is to provide pre-habilitation services prior to a period of bed rest. It is the intent of this study to examine the effectiveness of pre-habilitation exercises, compared to traditional rehabilitation, using an animal model of bed rest. Changes in walking ability, muscle function and stiffness, and bone mass and strength will be examined in young and old animals receiving pre-habilitation exercise before simulated bed rest. These will be compared to gains made in young and old animals receiving rehabilitation exercise after simulated bed rest. If preliminary findings are confirmed, it would provide support for appropriate human studies, and for expansion of habilitation services to older adults to include both pre-habilitation and rehabilitation.

描述（改编自申请人摘要）：卧床休息次要于

项目成果

Ovariectomy prevents the recovery of atrophied gastrocnemius skeletal muscle mass.

• DOI: 10.1152/japplphysiol.00869.2005
• 发表时间: 2006
• 期刊: Journal of applied physiology
• 影响因子: 3.3
• 作者: Mitchell Sitnick;Andrea M. Foley;Marybeth Brown;E. Spangenburg

Differential effectiveness of low-intensity exercise in young and old rats.

低强度运动对年轻和年老大鼠的不同效果。

• DOI: 10.1093/gerona/58.10.b889
• 发表时间: 2003
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Brown,Marybeth;Taylor,Jennifer;Gabriel,Rob
• 通讯作者: Gabriel,Rob

Gonadectomy and reduced physical activity: effects on skeletal muscle.

性腺切除术和减少体力活动：对骨骼肌的影响。

• DOI: 10.1053/apmr.2001.18697
• 发表时间: 2001
• 期刊: Archives of physical medicine and rehabilitation.
• 作者: Brown,M;Fisher,JS;Hasser,EM
• 通讯作者: Hasser,EM

Ovariectomy, hindlimb unweighting, and recovery effects on skeletal muscle in adult rats.

卵巢切除、后肢减重和对成年大鼠骨骼肌恢复的影响。

• 发表时间: 2005
• 期刊: Aviation, space, and environmental medicine.
• 作者: Brown,Marybeth;Foley,Andrea;Ferreria,JAndries
• 通讯作者: Ferreria,JAndries

A rehabilitation exercise program induces severe bone mineral deficits in estrogen-deficient rats after extended disuse.

长期停用后，康复锻炼计划会导致缺乏雌激素的大鼠出现严重的骨矿物质缺乏。

• DOI: 10.1097/gme.0b013e318255657f
• 发表时间: 2012
• 期刊: Menopause (New York, N.Y.)
• 作者: Yarrow,JoshuaF;McCoy,SeanC;Ferreira,JAndries;Pingel,JenniferE;Conrad,BryanP;Wronski,ThomasJ;Williams,AlyssaA;Borst,StephenE;Brown,Marybeth
• 通讯作者: Brown,Marybeth