ALPHA BETA T CELL INDEPENDENT B CELL FUNCTION

描述(改编自《调查者摘要》)：先天小鼠 缺乏α/βT细胞通常表现为高水平的血清 免疫球蛋白(Ig)。这些免疫球蛋白都是同种类型的，这令人惊讶 鉴于免疫球蛋白，特别是免疫球蛋白E的合成依赖于 T细胞。因此，B细胞成熟的一种新途径似乎是 在α/βT细胞缺陷小鼠中有效。这个想法得到了我们的支持 发现这样的小鼠也会发展生发中心、解剖部位 与依赖T细胞的B细胞成熟有关。调查人员， 因此，假设这些小鼠表现出迄今未见的特征 B细胞和非α/βT细胞的T-B协作能力。 在这些细胞中值得注意的是伽马/德尔塔T细胞，它们最近 通过证明小鼠体内唯一的 T细胞是伽马/德尔塔T细胞，也显示生发中心。伽马/三角洲 到目前为止，T细胞还没有被归因于B细胞的效应功能 成熟。为了验证他们的假设，他们计划将B细胞 α/βT细胞缺陷小鼠的生物学。有趣的是，这些抗体 在阿尔法/贝塔T细胞缺陷小鼠中形成的主要是自身反应， 靶向与人类狼疮患者相同的一组抗原。 其他最近得出的数据表明，α/βT细胞缺陷 老鼠确实患上了一种类似狼疮的疾病。因此，调查人员， 相信对这一途径的描述可以揭示 免疫缺陷相关的自身免疫综合征，如 在艾滋病患者中报告，如可能在一个或多个 更多的狼疮患者队列。

DESCRIPTION (Adapted from Investigator's abstract): Mice congenitally lacking alpha/beta T-cells frequently display high levels of serum immunoglobulins (Igs). These Igs are of all isotypes which is surprising given the established dependence of IgG, and particularly IgE synthesis, on T-cells. Therefore, a novel pathway of B-cell maturation would appear to be active in alpha/beta T-cell deficient mice. This idea is supported by our finding that such mice also develop germinal centers, anatomical sites associated with T-cell-dependent B-cell maturation. The investigators, therefore, hypothesize that these mice display an heretofore uncharacterized capacity to T-B collaboration between B-cells and non alpha/beta T-cells. Notable among such cells are gamma/delta T-cells, that they have recently shown to "help" B-cells, by demonstrating that mice in which the only T-cells are gamma/delta T-cells, also display germinal centers. Gamma/delta T-cells have not heretofore been ascribed an effector function in B-cell maturation. To test their hypothesis, they plan to characterize B-cell biology in alpha/beta T-cell deficient mice. Interestingly, the antibodies formed in alpha/beta T-cell deficient mice are largely auto-reactive, targeting the same set of antigens as are targeted in human lupus patients. Other recently-derived data demonstrate that alpha/beta T-cell deficient mice indeed develop a lupus-like disease. The investigators, therefore, believe that characterization of the pathway can shed light on immuno-deficiency-associated autoimmune syndromes, such as have been reported in individuals with AIDS, and such as may be operative in one or more cohorts of lupus patients.