REGULATION OF T CELL RECEPTOR GENE DIFFERENTIATION

描述：（改编自申请人的摘要）所有已知的脊椎动物 含有三组淋巴细胞、B细胞、α/β（ab）T细胞， γ/δ（gd）T细胞，由它们各自的抗原受体定义。 gd T细胞在宿主保护和维持中的作用很差 了解，许多旨在解决这个问题的研究已经比较， 将gd T细胞与其他两种类型的淋巴细胞进行对比。 有趣的是，gd T细胞的新功能特性表明， 它们可能具有迄今为止被认为是B细胞特异性或AB细胞特异性的特征， T细胞特异性的 在本申请中，描述了将继续我们的研究的研究。 gd T细胞发育的检查。 再次，新的信息表明， 一些gd T细胞与ab T细胞高度相似， 相同的血统，而其他人是B细胞样的，甚至是胸腺外的 推导 申请书列出了七个具体目标， 可以证实这种gd T细胞发育的“双途径”观点，并提供 关于发育如何被调节的重要的机械学见解。 等 知识可以显著改善我们对T细胞 发展 此外，它还提供了T细胞发育的指导。 在自身免疫的情况下， 免疫缺陷或移植。

DESCRIPTION: (Adapted from the applicant's abstract) All known vertebrates harbor three sets of lymphocytes, B cells, alpha/beta (ab) T cells, and gamma/delta (gd) T cells, defined by their respective antigen receptors. The role of gd T-cells in host protection and maintenance is poorly understood, and many studies aimed at resolving this have compared and contrasted gd T cells with the other two types of lymphocytes. Interestingly, emerging functional properties of gd T-cells suggest that they may share features hitherto regarded as B-cell-specific or ab T-cell-specific. In this application, studies are described that will continue our examination of gd T-cell development. Again, emerging information indicates that some gd T cells are highly similar to ab T cells, being derived from the same lineage, whereas others are B-cell like, even being extrathymically derived. The application lists seven specific aims, the success of which can confirm this "dual pathway" view of gd T-cell development and provide important mechanistic insight into how development is regulated. Such knowledge can significantly improve our basic depiction of T-cell development. In addition, it provides guidance as to how T-cell development might be experimentally manipulated in cases of autoimmunity, immunodeficiency, or transplant.