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T CELL MEMORY TO RESPIRATORY VIRUSES

呼吸道病毒的 T 细胞记忆

基本信息

批准号：
6169279
负责人：
PETER C DOHERTY
金额：
$ 18.28万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-04-01 至 2001-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6169279
关键词：
MHC class II antigen T cell receptor cytotoxic T lymphocyte helper T lymphocyte immunologic memory influenzavirus A laboratory mouse leukocyte activation /transformation parainfluenza virus type 1 tissue /cell culture

项目摘要

Respiratory virus infections ar a major problem for the aged, the very young, and a common complicating factor in immunocompromised transplant or cancer patients. In this context, the practical challenges are to develop better vaccines and enhanced mechanisms for maintaining and manipulating the cell populations that comprise immunological memory. The obverse of this problem is the desire to subvert the consequences of prior antigen priming in, for example, the use of virus-vector systems for gene therapy of cystic fibrosis. An underlying difficulty for both sets of approaches is that immunological memory is, in general, poorly understood. The experimental dissection of memory is technically demanding, rigorous analytical approaches have often been lacking, and there is substantial controversy and confusion. Many of the studies with non-viral systems are of limited value, as the experiments have been done with phenotypically- marked lymphocyte populations of unknown antigen specificity. Considerable effort has thus been made to develop mouse models for the quantitative, functional analysis of T cell memory to a parainfluenza type 1 virus (Sendai) and to the influenza A viruses. The intention is to use these experimental systems for the further clarification of the establishment, maintenance and recall phase of virus-specific CD4+ and CD8+ T cell memory. Attention will be given to the relative significance of events driven via the clonotypic T cell receptor for antigen, and the possible consequences of both intercurrent infections and more physiologically-mediated processes associated with the maintenance of homeostasis in the total pool of T lymphocytes. The experiments will inevitably lead to better understanding of the nature of T cell memory, and help provide novel insights for both vaccine development and possible therapy.

呼吸道病毒感染是老年人、老年人的一个主要问题年轻，是免疫功能低下的移植或移植中常见的并发症因素癌症患者。在此背景下，实际挑战是发展更好的疫苗和增强的维持和操纵机制构成免疫记忆的细胞群。正面为这个问题是想要颠覆先前抗原的后果例如，启动使用病毒载体系统进行基因治疗囊性纤维化。两组方法的根本困难一般来说，我们对免疫记忆知之甚少。这记忆的实验性解剖技术要求高、严谨往往缺乏分析方法，并且存在大量争议和困惑。许多非病毒系统的研究都是价值有限，因为实验是在表型上进行的未知抗原特异性的标记淋巴细胞群。大量因此，我们努力开发用于定量、 T 细胞对 1 型副流感病毒记忆的功能分析（仙台）和甲型流感病毒。目的是利用这些实验系统的建立进一步明确，病毒特异性 CD4+ 和 CD8+ T 细胞记忆的维持和回忆阶段。将关注通过以下方式驱动的事件的相对重要性抗原的克隆型 T 细胞受体以及可能的后果并发感染和更多生理介导的过程与总 T 池内稳态的维持有关淋巴细胞。实验将不可避免地带来更好的理解 T 细胞记忆的本质，并有助于为两者提供新颖的见解疫苗开发和可能的治疗方法。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Quantitative analysis of the CD8+ T-cell response to readily eliminated and persistent viruses.

DOI：
10.1098/rstb.2000.0647
发表时间：
2000-08
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
0
作者：
Peter C. Doherty;J. Riberdy;Gabrielle T. Belz
通讯作者：
Peter C. Doherty;J. Riberdy;Gabrielle T. Belz

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.

鼠伽马疱疹病毒的免疫控制不依赖于 CD8 T 细胞。