CORE--ANIMAL FACILITY

裸质粒DNA皮内基因免疫啮齿类动物的研究 先前已经显示pDNA（pDNA）偏离正在进行的Th2免疫应答。 介导的IgE应答为主的Th1应答。 为了 测试进一步完善的疫苗接种策略，并阐明细胞 参与这种现象的机制， 建议进行广泛的啮齿动物研究。 因此，动物核心将是 建立以1）繁殖并提供足够数量的小鼠， 个体研究者不能普遍获得的菌株， 2)定期向调查人员提供技术援助， 对老鼠进行打孔、放血和注射，以及3）提供服务， 科学研究人员通过协助动物护理，药物 行政和特别程序。

Intradermal gene vaccination of rodents with naked plasmid DNA (pDNA) has been previously shown to deviate an ongoing Th2 mediated IgE response to a predominately Th1 response. In order to test further refined vaccination strategies and elucidate the cellular mechanisms involved in t his phenomenon individual investigators have proposed extensive rodent studies. Therefore an Animal Core will be established to 1) breed and provide sufficient number of mice from strains that are not commmerically available to individual investigators, 2) routinely provide technical assistance to the investigators with ear punching, bleeding and injecting mice, and 3) provide service to scientific investigators by assisting with animal care, drug administratioin and special procedures.