CORE--ANIMAL FACILITY

裸质粒DNA皮内基因免疫啮齿动物的实验研究 (PDNA)之前已被证明偏离了正在进行的Th2 介导的IgE应答主要是Th1应答。为了 测试进一步改进的疫苗接种策略并阐明细胞 个别调查人员认为，这一现象涉及的机制 提议进行广泛的啮齿动物研究。因此，一个动物核心将是 建立的目的是1)繁殖和提供足够数量的小鼠 个体研究人员一般不能获得的菌株， 2)定期为有耳调查人员提供技术帮助 给老鼠打拳、放血和注射，以及3)提供服务 科学研究人员通过协助动物护理、药物 行政和特别程序。

Intradermal gene vaccination of rodents with naked plasmid DNA (pDNA) has been previously shown to deviate an ongoing Th2 mediated IgE response to a predominately Th1 response. In order to test further refined vaccination strategies and elucidate the cellular mechanisms involved in t his phenomenon individual investigators have proposed extensive rodent studies. Therefore an Animal Core will be established to 1) breed and provide sufficient number of mice from strains that are not commmerically available to individual investigators, 2) routinely provide technical assistance to the investigators with ear punching, bleeding and injecting mice, and 3) provide service to scientific investigators by assisting with animal care, drug administratioin and special procedures.