IMMUNE DEVIATION INDUCED BY GENE VACCINATION--APPLICATIONS TO ARTHRITIS
基因疫苗接种引起的免疫偏差——在关节炎中的应用
基本信息
- 批准号:6487293
- 负责人:
- 金额:$ 15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-01 至 2002-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Rheumatoid arthritis is a chronic inflammatory disease primary affecting
peripheral synovial joints. The etiopathogenesis of rheumatoid arthritis
appears to be multi-factorial, including hereditary susceptibility,
postnatal events in immune maturation, repeated exposure to environmental
antigens and amplifying cytokine networks that perpetuate inflammation.
The causative antigens may be directly expressed at the site of immune
attack pr be cross reactive with antigenic epitopes naturally occurring in
the joint. We postulate that stimulating a subset of T cells that respond
to a joint specific antigen to secrete IL4 or IL10 by manipulating the
antigen presenting environment may abrogate disease. In our preliminary
experiments we have developed a system whereby limited epitopes are
expressed by plasmid DNA injected into the dermis or muscle tissues of
mice. The T cell response to these antigens is additionally biased not
only by the epitope expressed, but also by different co-stimulatory
molecules expressed in the vicinity. This method of providing different
elements involved in priming of an immune response creates a local
immunologic window. In our laboratory we have also developed a unique
system to limit antigen presentation to an isoform of CD1. We aim to 1)
assess the effects of different co-stimulatory molecules on deviating the
immune response to collagen 2) determine if providing additional antigenic
chaperones or covalently linking the antigen chaperones potentiates immune
deviation 3) evaluate a regulatory role for the CD1D1 restricted responses
in collagen induced arthritis and 4) determine if the findings form our
three strategies in the collagen induced arthritis model apply to a
different transgenic mouse model in which the mice spontaneously develop
arthritis.
类风湿性关节炎是一种原发性慢性炎症性疾病
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('MARY P Corr', 18)}}的其他基金
Resource-based Center for the study of the joint microenvironment in rheumatology (Overall Application)
风湿病关节微环境研究资源中心(综合应用)
- 批准号:
10472681 - 财政年份:2018
- 资助金额:
$ 15万 - 项目类别:
TLR-7 Agonists as Targeted Anti-inflammatory Agents in Arthritis
TLR-7 激动剂作为关节炎的靶向抗炎药
- 批准号:
8302750 - 财政年份:2012
- 资助金额:
$ 15万 - 项目类别:
TLR-7 Agonists as Targeted Anti-inflammatory Agents in Arthritis
TLR-7 激动剂作为关节炎的靶向抗炎药
- 批准号:
8472443 - 财政年份:2012
- 资助金额:
$ 15万 - 项目类别:
IMMUNE DEVIATION INDUCED BY GENE VACCINATION--APPLICATIONS TO ARTHRITIS
基因疫苗接种引起的免疫偏差——在关节炎中的应用
- 批准号:
6663346 - 财政年份:2002
- 资助金额:
$ 15万 - 项目类别:
IMMUNE DEVIATION INDUCED BY GENE VACCINATION--APPLICATIONS TO ARTHRITIS
基因疫苗接种引起的免疫偏差——在关节炎中的应用
- 批准号:
6352672 - 财政年份:2000
- 资助金额:
$ 15万 - 项目类别:
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