IRON STATUS AND RISK OF CHD AND COLON CANCER

描述：（改编自研究者摘要）研究者 建议前瞻性地检查铁状态（摄入量， 和遗传易感性）和风险 心肌梗死（MI）和结直肠癌的三个大型队列。 铁摄入量采用半定量食物频率问卷进行评估 （SFFQ）在1980年的护士健康研究（NHS，n= 121，700名女性）和 1986年在NHS和卫生专业人员随访研究（HPFS， n= 51，529名男性）。 在这两个队列中收集血液样品： 1989- 1990年的NHS（n= 32，825名女性）和1993- 1994年的HPFS（n= 18，000名男性）。 此外，还从参与者中收集了样本， 1982年医生健康研究（PHS，n= 14，916名男性）。 这些男人和女人 最初没有心血管疾病和癌症， 前瞻性地预测心血管疾病和癌症的发生。 的 研究者计划在巢式病例对照设计中分析样本， 对于身体铁储存的生物标志物（铁，总铁结合能力， 铁蛋白）和遗传标记的血色病，一种遗传性疾病， 铁超载（C282 Y，HLA-H基因的错义突变）。 的 铁-CHD/癌症假说已经得到实验室和动物实验支持 研究，但从小的，不太全面的流行病学研究结果 不一致。 他们建议评估以下个体的关联： 摄入量、生物标志物水平和基因型与MI和结直肠癌风险 癌症，以及综合效应。 此外，他们将评估其他 饮食和生活方式因素可能解释或改变这种关联 铁与心肌梗死/结直肠癌之间的关系 正在进行的三个组群将 提供高产出的后续参与和高质量的终点 除了关于重要变量的信息（例如， 吸烟，维生素补充剂的使用，饮食因素）的拟议研究。 这些分析将利用现有的血库， 充分表征的队列，以及部分血浆铁蛋白测量 (the NHS和PHS）通过其他来源供资。 调查人员表示， 因此，该应用程序提供了一个重点突出， 成本效益高，全面的方法来评估假设，但 铁作为未来心血管疾病危险因素的作用尚未得到证实， 癌

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose to examine prospectively the relation between iron status (intake, body stores, and genetic susceptibility for hemochromatosis) and risk of myocardial infarction (MI) and colorectal cancer in three large cohorts. Iron intake was assessed by semiquantitative food frequency questionnaire (SFFQ) in 1980 in the Nurses' Health Study (NHS, n=121,700 women) and in 1986 in the NHS and in the Health Professionals Follow-up Study (HPFS, n=51,529 men). Blood samples were collected in both of these cohorts: from the NHS in 1989-90 (n=32,825 women), and the HPFS in 1993-94 (n=18,000 men). In addition, samples also were collected from participants in the Physicians' Health Study in 1982 (PHS, n=14,916 men). These men and women initially free of cardiovascular disease and cancer and have been followed prospectively for the occurrence of cardiovascular disease and cancer. The investigators plan to assay the samples, in a nested case-control design, for biomarkers of body iron stores (iron, total iron binding capacity, ferritin) and genetic marker of hemochromatosis, an inherited disease of iron overload (C282Y, a missense mutation in HLA-H gene). The iron-CHD/cancer hypotheses have been supported by laboratory and animal studies, but findings from small, less comprehensive epidemiologic studies are inconsistent. They propose to evaluate the individual associations of intake, biomarker levels, and genotype with risk of MI and colorectal cancer, as well as the combined effects. Further, they will evaluate other dietary and lifestyle factors that may account for or modify the association between iron and MI/colorectal cancer. The ongoing three cohorts will provide high yield follow-up participation and high quality end-point verification in addition to information on important variables (e.g., smoking, vitamin supplement use, dietary factors) for the proposed study. These analyses will take advantage of existing blood banks of these well-characterized cohorts, and part of the plasma ferritin measurements (the NHS and PHS) are funded through other sources. The investigators state that hence, this application provides a well-focused, efficient cost-effective, and comprehensive approach to evaluate the hypothesized but unproven role of iron as a risk factor for future cardiovascular disease and cancer.