IN SITU FORCES IN NORMAL AND RECONSTRUCTED ACLS

描述（改编自申请人的摘要）： 前交叉韧带（ACL）缺乏是常见的，但不幸的是，没有 一次手术就能使膝关节运动恢复到损伤前水平 程度. 事实上，国际膝关节文献委员会 （IKDC）指南，38%的患者报告有异常，或 严重异常的膝盖 因此，手术ACL的进步 重建和术后康复，以改善结果， 需要更好地了解完整ACL的受力情况。 的 该项目的主要目的是研究现场力量及其 在外部载荷下ACL和ACL置换移植物内的分布， 有和没有肌肉稳定。 申请人认为， 完整的ACL是ACL重建的真正“金标准”。 使用 尸体膝关节，原位力和膝关节运动学的数据将 获得并用于评价ACL重建，特别是重要的 变量如移植物类型、束数和切迹成形术。 的 研究人员将使用新开发的机器人/通用力矩 传感器（UFS）测试系统，以确定原位力和膝关节 运动学 将在6个自由度（DOF）中进行复杂的人体膝关节运动。 记录下来，然后用机器人操作器复制出来。 原地力 完整ACL及其置换移植物将从力数据中获得 由UFS测量。 此外，这项技术将产生关于 ACL重建后继发的膝关节运动学变化。 相同的 可以使用一个样本进行一系列测试， 接头作为其自身对照（从而最大限度地减少样本间 变化）。 据建议，从拟议的 本研究将有助于ACL缺陷的临床治疗。 是 申请人的目标是为外科医生提供数据， 适当的ACL置换移植物和重建手术，以及 改进康复方案。 从长远来看，他们认为， 机器人/UFS测试系统可用于再现膝关节运动学数据 从尸体膝关节的体内活动中获得。 因此， 力和力分布在ACL和置换移植物中， 日常生活和运动活动可以间接确定。

DESCRIPTION (Adapted from the Applicant's Abstract): Surgical treatment of anterior cruciate ligament (ACL) deficiency is common, but unfortunately, no single procedure has been able to restore knee kinematics to pre-injury levels. In fact, using the International Knee Documentation committee (IKDC) guidelines, 38% of the patients were reported to have abnormal, or severely abnormal knees. Therefore, advancements in surgical ACL reconstruction, and post-operative rehabilitation to improve the outcome, would require a better understanding of the forces in the intact ACL. The broad aim of this project is to examine the in situ force and its distribution within the ACL and ACL replacement grafts under external loads, with and without muscle stabilization. It is the applicants' belief, that the intact ACL is the true "gold standard" for ACL reconstruction. Using cadaveric knees, data on both the in situ forces and knee kinematics will be obtained and used to evaluate ACL reconstruction, particularly on important variables such as graft type, number of bundles, and notchplasty. The investigators will use a newly developed robotic/universal force-moment sensor (UFS) testing system to determine the in situ forces and knee kinematics. Complex human knee motion in 6 degrees-of-freedom (DOF) will be recorded and then reproduced using a robotic manipulator. In situ forces in the intact ACL and its replacement grafts will be obtained from force data measured by the UFS. Further, this technology will yield data on the changes in knee kinematics secondary to ACL reconstruction. The same specimen can be utilized for a series of tests, allowing the intact knee joint to serve as its own control (thus minimizing interspecimen variations). It is suggested that information obtained from the proposed studies will be useful for the clinical management of ACL deficiency. It is the applicants' goal to provide data for surgeons to help them select appropriate ACL replacement grafts and reconstruction procedures, and to improve rehabilitation protocols. In the long-term, they believe that the robotic/UFS test system can be used to reproduce the knee kinematics data obtained from in vivo activities on cadaveric knees. Thus, the in situ forces and force distribution in the ACL and replacement grafts during the activities of daily living and sports could be indirectly determined.