Training in Biomechanics in Regenerative Medicine

再生医学生物力学培训

• 批准号: 8264738
• 负责人: SAVIO L-Y. WOO
• 金额: $ 25.64万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264738
• 关键词: Biomechanics; Regenerative Medicine; Training

DESCRIPTION (provided by applicant): The Departments of Bioengineering at the University of Pittsburgh (UOP) and Biomedical Engineering at Carnegie Mellon University (CMU) are seeking continued support for a predoctoral training program (6 positions total per year) aimed at providing a solid foundation upon which to build a productive and independent career in biomechanics as applied to regenerative medicine (BiRM). This goal is accomplished through a highly coordinated and mentored interdisciplinary program that combines required and elective courses, research activities, and specialized training opportunities. The Training Program incorporates faculty from the Departments of Bioengineering (UOP), Biomedical Engineering (CMU), and Mechanical Engineering (UOP and CMU), and the UOP School of Medicine Departments of Orthopedic Surgery, Vascular Surgery, Urology, and the McGowan Institute for Regenerative Medicine. This unique combination of training faculty research interests and coursework provides a rich educational experience and more numerous training opportunities for students than could be obtained within the individual university departments. The breadth of research areas that span multiple physiological systems (cardiovascular, musculo-skeletal, urological) provides a unique opportunity for students to become highly skilled problem solvers by appreciating generalized approaches that are system-independent. Moreover, the since the BiRM program is not central to any one department, it provides students with inter-departmental didactic and research experience - overcoming the departmental based administrative roadblocks that traditionally exist in conventional programs., By permitting a much wider choice of options with which to pursue a PhD in developing and applying biomechanical approaches to regenerative medicine research. the BiRM program permits ever increasing educational options for the students and research collaborations. Candidate BiRM fellows are drawn primarily from engineering schools, although the program also welcomes students from biology, physics, chemistry, and mathematics. Program coursework (didactic courses, lecture series, workshops) is designed to provide both breadth and depth in engineering and biological sciences and also includes a formal exposure to biostatistics, bioethics, and professional and career development. Finally, each student receives extensive research training in the laboratories of the training faculty. Twelve predoctoral trainees have participated in the program during the current (first) cycle and we believe that the trainee performance and program outcomes have been outstanding (see Progress Report). PUBLIC HEALTH RELEVANCE: Regenerative medicine uses a variety of approaches, such as tissue engineering, cellular therapies, biosurgery and artificial and biohybrid organ devices, to address tissue/organ insufficiency. Yet, despite several early successes, bioengineers have faced challenges in repairing or replacing tissues that serve a predominantly biomechanical function. Therefore, we believe that individuals trained in both biomechanical engineering principles and biology are critically needed to develop novel therapeutic approaches for advancing regenerative medicine therapies. The proposed program aims to provide such training to students pursuing a doctoral degree in bioengineering.

描述（由申请人提供）：匹兹堡大学（UOP）生物工程系和卡内基梅隆大学（CMU）生物医学工程系正在寻求对博士前培训计划（每年6个职位）的持续支持，旨在为应用于再生医学（BiRM）的生物力学提供坚实的基础。这一目标是通过一个高度协调和指导的跨学科计划，结合必修和选修课程，研究活动和专业培训机会来实现的。该培训计划包括来自生物工程（UOP），生物医学工程（CMU）和机械工程（UOP和CMU）部门的教师，以及骨科手术，血管外科，泌尿外科和麦高恩再生医学研究所的UOP医学院。这种培训教师研究兴趣和课程的独特组合为学生提供了丰富的教育经验和更多的培训机会，而不是在各个大学部门内获得。跨越多个生理系统（心血管，肌肉骨骼，泌尿系统）的研究领域的广度为学生提供了一个独特的机会，通过欣赏系统独立的广义方法成为高技能的问题解决者。此外，由于BiRM计划不是任何一个部门的中心，它为学生提供跨部门的教学和研究经验-克服传统计划中传统上存在的部门管理障碍。通过允许更广泛的选择，以追求博士学位的发展和应用生物力学方法再生医学研究。BiRM计划允许不断增加的学生和研究合作的教育选择。候选BiRM研究员主要来自工程学校，尽管该计划也欢迎来自生物，物理，化学和数学的学生。计划课程（教学课程，系列讲座，研讨会）旨在提供工程和生物科学的广度和深度，还包括正式接触生物统计学，生物伦理学以及专业和职业发展。最后，每个学生在培训学院的实验室接受广泛的研究培训。在当前（第一个）周期中，有12名博士前学员参加了该计划，我们认为学员的表现和计划成果都很出色（见进度报告）。 公共卫生相关性：再生医学使用各种方法，如组织工程，细胞疗法，生物外科和人工和生物混合器官装置，以解决组织/器官功能不全。然而，尽管有一些早期的成功，生物工程师在修复或替换主要发挥生物力学功能的组织方面面临着挑战。因此，我们认为，迫切需要在生物力学工程原理和生物学方面受过训练的个人来开发新的治疗方法，以推进再生医学疗法。拟议的计划旨在为攻读生物工程博士学位的学生提供此类培训。