HEALING OF THE MCL--INTERDISCIPLINARY STUDIES

该项目的主要目标是将 细胞的形态、生物力学和生化特性 滑膜关节模型中的韧带愈合过程。临床医生 经常需要做出关于膝部治疗的决定 涉及一条以上韧带损伤的损伤。然而， 单膝韧带的首选治疗方法可能有很大不同 换成另一条膝盖韧带。最近，孤立的医疗中心 侧副韧带(MCL)损伤已得到治疗 非手术的，而外科重建经常是 推荐用于前十字韧带撕裂(ACL)。 通常，损伤涉及MCL和前交叉韧带，但 前交叉韧带重建对MCL愈合的影响尚未见报道 定义，也没有额外治疗的有效性 养生法。 这些复合损伤的次优治疗通常会导致 到持续的关节不稳定。尽管各种治疗方法都有 被推荐，但很少有客观比较他们的 结果。因此，我们设计了研究来评估 ACL等变量的影响和相互关系 横切术，前交叉韧带重建，每日外翻负荷程序，以及 生长因子对MCL愈合过程的影响。我们还将评估 MCL的功能作用及其损伤和后续 愈合会改变膝关节的运动学。伤病 模型将包括MCL破裂；严重损害 韧带中间物质及其在骨中的附着点。时间进程 MCL愈合长达一年的情况将从形态上进行研究， 从生物力学和生化角度来看。所获得的相关数据 通过这些跨学科的方法，我们应该能够更好地 了解MCL物质的愈合过程和 韧带插入骨骼。我们预计这样的知识 最终将导致改善对慢性阻塞性肺疾病患者的治疗 MCL+前交叉韧带联合损伤。

The primary objective of this project is to correlate the morphological, biomechanical, and biochemical properties of the ligament healing processes in a model synovial joint. Clinicians often need to make decisions regarding the treatment of knee injuries involving damage to more than one ligament. However, the preferred treatment for one knee ligament may be very different from that for another knee ligament. Recently, isolated medial collateral ligament (MCL) injuries have been treated non-operatively, whereas surgical reconstruction is frequently recommended for a torn anterior cruciate ligament (ACL). Frequently, injuries involve both the MCL and ACL, and yet, the influence of ACL reconstruction on MCL healing has not been defined, nor has the effectiveness of additional treatment regimens. The suboptimal treatment of these combined injuries generally leads to persistent joint instability. Although various treatments have been recommended, there are few objective comparisons of their results. Therefore, we have designed studies to evaluate the influence and interrelationship of variables such as ACL transection, ACL reconstruction, daily valgus loading programs, and growth factors on the MCL healing process. We also will evaluate the functional role of the MCL and how its injury and subsequent healing would change the kinematics of the knee joint. The injury model will include rupture of the MCL; severely damaging both the ligament midsubstance and its insertions to bone. The time course of MCL healing up to one year will be studied morphologically, biomechanically, and biochemically. The correlated data obtained from these interdisciplinary approaches should permit us to better understand the healing processes of both the MCL substance and the ligament insertions to bone. We anticipate that such knowledge will ultimately lead to improved treatment for patients with combined MCL+ACL injuries.