ZINC SUPPLEMENTATION IN CROHN'S DISEASE PATIENTS

说明(改编自应用程序) 营养缺乏似乎在克罗恩病患者中很常见，但 纠正具体缺陷的好处在很大程度上仍不清楚。这 该项目测试了一种假设，即增加锌的摄入量，通过受试者 活动性克罗恩病(N=15)，有益于一般测量 锌功能、克罗恩病活动指数、免疫功能和游离 自由基介导的氧化应激。结果将与安慰剂效果进行比较 其他克罗恩病(N=15)。该项目的每一位患者都将展示 以淋巴细胞锌值为基础的中度缺锌。免疫功能和 将对氧化应激进行研究，因为两者都会影响整体健康，而且两者 似乎影响肠道炎症，这是克罗恩病的主要病理。 每天补充45毫克的锌可以增加锌的摄入量(3 乘以USRDA)，为期10周。补充剂将是甘氨酸络合锌， 它比氧化锌吸收得更好，后者出现在许多 复合维生素矿物片。免疫功能将通过血液进行监测 符合两个标准的测量：克罗恩病中出现异常值 而已知的是，锌的状况会影响这些价值。氧化应激 将在结肠活检样本中进行评估。CDAI中的任何改进，或 免疫功能或氧化应激的测量结果将与 血液或结肠指标的变化一般要检测锌的功能状态 寻找可能的关联。该项目的积极成果将导致 扩展版本，检查更多主题，延长补充内容 期间，将锌补充剂与其他营养素的补充剂结合起来，考虑 饮食干预，增加锌的摄入量，并长期检查 病理症状评估。

DESCRIPTION (adapted from the application) Nutritional deficiencies seem common in Crohn's disease patients, but the benefits of correcting specific deficiencies remain largely unclear. This project tests the hypothesis that increased zinc intake, by subjects with active Crohn's disease (N=15), beneficially impacts measurements of general zinc function, Crohn's disease activity index (CDAI), immune function and free radical-mediated oxidant stress. Results will be compared to placebo effects in other Crohn's patients (N=15). Each of the project's patients will show moderate zinc deficiency based on lymphocyte zinc values. Immune function and oxidant stress will be studied because both affect overall health, and both seem to affect bowel inflammation, the primary pathology of Crohn's disease. Increased zinc intake would be accomplished by supplementation at 45 mg/day (3 times the USRDA) for 10 weeks. The supplement will be glycine-chelated zinc, which is better absorbed than zinc oxide, which appears in many multivitamin-mineral tablets. Immune function will be monitored by blood measurements meeting two criteria: abnormal values occur in Crohn's disease patients; and values are known to be affected by zinc status. Oxidant stress will be evaluated in colon biopsy samples. Any improvements in CDAI, or measurements for immune function or oxidant stress, will be compared with changes in blood or colon indicators of general zinc functional status to test for possible correlations. Positive results in this project will lead to expanded versions which examine more subjects, extend the supplementation period, combine zinc supplements with supplements of other nutrients, consider dietary food interventions which increase zinc ,intake, and examine long term assessment of pathology symptoms.