ZINC SUPPLEMENTATION IN CROHN'S DISEASE PATIENTS

克罗恩病患者补充锌

• 批准号: 6381201
• 负责人: ROBERT A DISILVESTRO
• 金额: $ 2.06万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6381201
• 关键词: Crohn's disease; clinical research; diet therapy; dietary supplements; dietary trace element; human subject; human therapy evaluation; immunoregulation; nutrition related tag; oxidative stress; zinc

DESCRIPTION (adapted from the application) Nutritional deficiencies seem common in Crohn's disease patients, but the benefits of correcting specific deficiencies remain largely unclear. This project tests the hypothesis that increased zinc intake, by subjects with active Crohn's disease (N=15), beneficially impacts measurements of general zinc function, Crohn's disease activity index (CDAI), immune function and free radical-mediated oxidant stress. Results will be compared to placebo effects in other Crohn's patients (N=15). Each of the project's patients will show moderate zinc deficiency based on lymphocyte zinc values. Immune function and oxidant stress will be studied because both affect overall health, and both seem to affect bowel inflammation, the primary pathology of Crohn's disease. Increased zinc intake would be accomplished by supplementation at 45 mg/day (3 times the USRDA) for 10 weeks. The supplement will be glycine-chelated zinc, which is better absorbed than zinc oxide, which appears in many multivitamin-mineral tablets. Immune function will be monitored by blood measurements meeting two criteria: abnormal values occur in Crohn's disease patients; and values are known to be affected by zinc status. Oxidant stress will be evaluated in colon biopsy samples. Any improvements in CDAI, or measurements for immune function or oxidant stress, will be compared with changes in blood or colon indicators of general zinc functional status to test for possible correlations. Positive results in this project will lead to expanded versions which examine more subjects, extend the supplementation period, combine zinc supplements with supplements of other nutrients, consider dietary food interventions which increase zinc ,intake, and examine long term assessment of pathology symptoms.

描述（改编自应用程序） 营养缺乏似乎在克罗恩病患者中很常见，但 纠正具体缺陷的好处在很大程度上仍不清楚。这 项目测试的假设，增加锌的摄入量，受试者与 活动性克罗恩病（N=15），有益地影响一般 锌功能、克罗恩病活动指数（CDAI）、免疫功能和游离 自由基介导的氧化应激。结果将与安慰剂效应进行比较， 其他克罗恩病患者（N=15）。该项目的每一位患者都将表现出 根据淋巴细胞锌值中度缺锌。免疫功能和 氧化应激将被研究，因为两者都会影响整体健康， 似乎影响肠道炎症，这是克罗恩病的主要病理。 增加锌的摄入量将通过补充45毫克/天来实现（3 USRDA）10周。补充剂是甘氨酸螯合锌， 它比氧化锌更容易被吸收，氧化锌出现在许多 多种维生素矿物质片免疫功能将通过血液监测 符合两个标准的测量：克罗恩病中出现异常值 患者;并且已知值受锌状态的影响。氧化应激 将在结肠活检样本中进行评估。CDAI的任何改善，或 免疫功能或氧化应激的测量，将与 改变血液或结肠指标的一般锌功能状态的测试 寻找可能的相关性。该项目的积极成果将导致 扩大版本，检查更多的科目，扩大补充 期间，联合收割机锌补充剂与其他营养素的补充，考虑 增加锌摄入量的膳食干预措施，并进行长期检查 病理学症状评估。