COMORBIDITY AND ADOLESCENT DRUG ABUSE TREATMENT

描述：（申请人摘要） 药物滥用和心理健康领域的研究人员和临床医生寻求 了解复杂性并掌握治疗的巨大挑战 患有药物滥用和精神疾病的患者。精神病 合并症影响成人药物滥用研究的治疗结果 已经进行了。对青少年药物滥用者的研究 揭示了社区和临床样本中精神病合并症的高发生率。 研究人员认为，考虑到青少年物质的异质性， 滥用时，可能会发生对治疗反应的重要变化， 共病精神问题的类型和严重程度。183名青少年 物质使用障碍者参加一项随机临床试验， 家庭治疗和个人认知行为治疗将包括 研究样本。这项研究的参与者主要是低收入的少数民族， 患有高比例共病的年轻人。青少年和他们的父母 在治疗开始时、治疗结束时以及6岁和12岁时进行访谈 一个月的随访，以确定他们的物质使用和精神 症状，以及家庭问题，包括父母的精神病理学。的 本B/START中提议的研究的目的是确定 精神共病的存在与以下变化有关： 为接受药物滥用治疗的青少年提供康复。这项研究有三个目标： 1)检查特定的精神病诊断是否与 青少年吸毒轨迹从吸毒开始到治疗结束， 随访6个月和12个月; 2）检查患者的精神症状是否严重， comorbital缓和药物使用和精神症状轨迹的变化 （三）研究父母改变对滥用药物青少年的态度， 精神病理学与青少年物质滥用的变化有关， 精神科合并症，以及治疗方式是否会调节这种情况 关系这项研究的结果将大大告知 制定和完善有效的药物滥用干预措施 患有不同类型和严重程度的共病精神问题的青少年。

DESCRIPTION: (Applicant's Abstract) Researchers and clinicians in the drug abuse and mental health fields seek to understand the complexities and master the enormous challenges of treating individuals with comorbid drug abuse and psychiatric disorders. Psychiatric comorbidity impacts treatment outcomes in studies with adult substance abuse have been conducted. Studies of adolescent substance abusers consistently reveal high rates of psychiatric comorbidity in community and clinical samples. Researchers have suggested that given the heterogeneity of adolescent substance abuse, important variations in response to treatment may occur based on the type and severity of comorbid psychiatric problems. 183 adolescents with a substance use disorder who participate in a randomized clinical trial comparing family therapy and individual cognitive-behavioral therapy will comprise the study sample. The participants in this study are largely low-income, minority youth with high rates of comorbid disorders. Adolescents and their parents were interviewed at intake to treatment, at the end of treatment, and at 6 and 12 month follow up to determine the level of their substance use and psychiatric symptoms, as well as family problems including parental psychopathology. The purpose of the study proposed in this B/START is to determine whether the presence of psychiatric comorbidity is related to changes in the rate of recovery for adolescents in treatment for drug abuse. The study has three aims: 1) To examine whether specific psychiatric diagnoses are related to changes in adolescent drug use trajectories from intake to the end of treatment and up to 6 month and 12 month follow up; 2) To examine whether severity of psychiatric comorbidity moderates changes in drug use and psychiatric symptom trajectories for adolescent substance abusers; and 3) To examine whether change in parental psychopathology is related to change in adolescent substance abuse and psychiatric comorbidity, and whether treatment modality moderates this relationship. The results of this study will significantly inform the development and refinement of effective interventions for substance abuse adolescents with varying types and severity of comorbid psychiatric problems.