COMORBIDITY AND ADOLESCENT DRUG ABUSE TREATMENT

描述：(申请人摘要) 药物滥用和精神健康领域的研究人员和临床医生试图 了解治疗的复杂性并掌握治疗的巨大挑战 同时患有药物滥用和精神障碍的个人。精神科 成人药物滥用研究中共病对治疗结果的影响 已经进行了。青少年物质滥用者的持续研究 在社区和临床样本中发现精神疾病共病的高比率。 研究人员认为，鉴于青少年物质的异质性 滥用，对治疗的反应可能发生重要的变化，基于 并存精神问题的类型和严重程度。183名患有老年痴呆的青少年 参加一项随机临床试验的物质使用障碍者 家庭治疗和个人认知行为治疗将包括 研究样本。这项研究的参与者主要是低收入的少数族裔 患有高共病障碍的年轻人。青少年和他们的父母 在接受治疗时、治疗结束时、6岁和12岁时进行访谈 一个月的随访，以确定他们的物质使用水平和精神疾病 症状，以及家庭问题，包括父母的精神病态。这个 本B/START中提出的研究的目的是确定 精神疾病共病的存在与精神疾病发生率的变化有关 青少年在药物滥用治疗中的康复。这项研究有三个目的： 1)检查特定的精神疾病诊断是否与 青少年药物使用轨迹从吸食到治疗结束 6个月和12个月随访；2)检查精神疾病的严重程度 共病缓解药物使用和精神症状轨迹的变化 对于青少年药物滥用者；以及3)检查父母是否改变了 精神病理学与青少年药物滥用的变化和 精神疾病的共病，以及治疗方式是否缓解了这种情况 两性关系。这项研究的结果将显著地为 制定和完善有效的药物滥用干预措施 患有不同类型和严重共病精神问题的青少年。

DESCRIPTION: (Applicant's Abstract) Researchers and clinicians in the drug abuse and mental health fields seek to understand the complexities and master the enormous challenges of treating individuals with comorbid drug abuse and psychiatric disorders. Psychiatric comorbidity impacts treatment outcomes in studies with adult substance abuse have been conducted. Studies of adolescent substance abusers consistently reveal high rates of psychiatric comorbidity in community and clinical samples. Researchers have suggested that given the heterogeneity of adolescent substance abuse, important variations in response to treatment may occur based on the type and severity of comorbid psychiatric problems. 183 adolescents with a substance use disorder who participate in a randomized clinical trial comparing family therapy and individual cognitive-behavioral therapy will comprise the study sample. The participants in this study are largely low-income, minority youth with high rates of comorbid disorders. Adolescents and their parents were interviewed at intake to treatment, at the end of treatment, and at 6 and 12 month follow up to determine the level of their substance use and psychiatric symptoms, as well as family problems including parental psychopathology. The purpose of the study proposed in this B/START is to determine whether the presence of psychiatric comorbidity is related to changes in the rate of recovery for adolescents in treatment for drug abuse. The study has three aims: 1) To examine whether specific psychiatric diagnoses are related to changes in adolescent drug use trajectories from intake to the end of treatment and up to 6 month and 12 month follow up; 2) To examine whether severity of psychiatric comorbidity moderates changes in drug use and psychiatric symptom trajectories for adolescent substance abusers; and 3) To examine whether change in parental psychopathology is related to change in adolescent substance abuse and psychiatric comorbidity, and whether treatment modality moderates this relationship. The results of this study will significantly inform the development and refinement of effective interventions for substance abuse adolescents with varying types and severity of comorbid psychiatric problems.