PRESCHOOL MOTOR & FUNCTIONAL PERFORMANCE OF TWO COHORTS

随着低出生体重婴儿存活率的提高， 早产儿随访研究的重点已经转移到更好地了解 围产期发病率的范围和性质。本项目的目的是 探讨早产与学龄前运动的关系， 按相似的围产期风险分类的两个队列的功能表现， 出生相隔十年。运动能力在四个特定领域进行评估： 一般运动、粗大运动、精细运动和视觉运动整合。 功能性能评估执行以下任务的持续能力： 日常生活和预期的社会角色。背景是主要的区域 高风险婴儿的护理来源，并取得了最高评级， 在生存期、住院时间和结局质量方面与其他患者相比。数据 队列1，出生于1985年至89年，作为188名研究的一部分， 对足月和早产儿从出生到 八岁。这个样本在4岁时表现出运动功能的实质性延迟， 与8岁时学校表现不佳的维度有关。这 申请要求资源，以招聘和进行完整的电机和 在4岁时对随后队列（队列2，出生于 1996年至97年，并按围产期风险进行相同分层。鉴于增加 脆弱性、出生体重较低和胎龄较低， 假设运动和功能表现会下降， 几十年之间。有两个具体目标。目标1研究了 新生儿重症监护室两例患者围产期运动和功能风险 存活者分层为：1）健康足月组; 2）早产/医学疾病 早产儿/神经系统疾病组。目标2比较了电机和 两个分层样本的功能表现。本申请是 独特之处在于它提供了提供关键信息的机会， 新生儿进展导致的运动后遗症，以及重复 在早期队列的儿童中发现的潜在有害结果。 队列比较结果对于了解整个范围至关重要 在先进的新生儿技术的时间框架内早产运动后遗症。

With increased survival rates for low birth weight infants, the focus of pre-term follow-up studies has shifted to gain a better understanding of the scope and nature of perinatal morbidity. The purpose of this project is to investigate the relationship between prematurity and preschool motor and functional performance in two cohorts categorized by similar perinatal risk and born ten years apart. Motor ability is evaluated in four specific areas: general motor, gross motor, fine motor, and visual motor integration. Functional performance evaluates the consistent ability to perform the tasks of daily living and expected social roles. The setting is the major regional source of care for high-risk infants and has achieved the highest ratings when compared to others in survival, length of stay and quality of outcome. Data for Cohort 1, born between 1985 to 89, were collected as part of a study of 188 full term and pre-term children who were studied longitudinally from birth to age 8. This sample showed substantial delays in motor function at age 4, which are associated with dimensions of poor school performance at age 8. This application requests resources to recruit and conduct complete motor and functional performance assessment of a later cohort at age 4, Cohort 2, born in 1996 to 97 and identically stratified by perinatal risk. Given the increased fragility, lower birthweight and younger gestational ages of Cohort 2, it is hypothesized that there will be a decline in motor and functional performance between decades. There are two specific aims. Aim 1 investigates the effects of perinatal risk on motor and functional performance in two samples of NICU survivors stratified as: 1) healthy full term group; 2) pre-term/medically ill group; and 3) pre-term/neurologically ill group. Aim 2 compares the motor and functional performance of the two stratified samples. This application is unique in that it affords the opportunity to provide critical information about motor sequelae resulting from new neonatal advances, as well as replicate potentially deleterious outcomes found in the children of the earlier cohort. Cohort comparison results are crucial in terms of understanding the full range of pre-term motor sequelae within a time frame of advanced neonatal technology.