Is oxidative stress the principal mode of toxicity for metal oxide nanoparticles?
氧化应激是金属氧化物纳米粒子的主要毒性模式吗?
基本信息
- 批准号:NE/H008764/1
- 负责人:
- 金额:$ 78.53万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2010
- 资助国家:英国
- 起止时间:2010 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Manufactured nanoparticles (NPs) can be defined as very small materials purposefully produced by human activity with at least one dimension between 1 and 100 nm (i.e. they are larger than most chemical products but much smaller than biological cells). They are currently of tremendous scientific, technological and economic importance, having a wide range of applications or potential applications in environmental technologies, medical and health applications (e.g. drug delivery vehicles, diagnostics, antibiotics), computing, cosmetics and elsewhere. Global research and development was valued at approximately £10 billion in 2006 and international nanotechnology markets are expected to be valued at trillions of dollars in the next decade. Given this huge and growing importance, concern is warranted because (1) discharges into the environment are now occurring and will grow at increasing rates as the nanotechnology industry increases, (2) significant adverse effects on human and environmental health have been shown to occur and yet there remains great uncertainty as to the type of damage that they may cause and whether this can lead to adverse health effects at exposure levels likely to be achieved in the environment. We seek to ensure responsible development of these hugely beneficial products. This is vital to ensure that industry and government (and ultimately the general public) are informed of the possible risks of NPs, so that these risks can be minimised and a large scale public backlash, such as occurred for genetically modified organisms, is prevented. Metal oxide NPs, especially TiO2 and CeO2, are amongst the most widely used NPs in consumer goods and it is almost certain that these NPs are present in the environment despite our lack of methods to measure concentrations under realistic conditions. There is evidence that both of these materials can lead to damage of biological cells and that this is caused by their ability to produce highly damaging forms of oxygen (called reactive oxygen species). However, there is very little information on whether such damage can occur in whole organisms, particularly in the freshwater environment, which is likely to be a major source of exposure. There is also very little information on whether other modes of toxicity are important. We wish to test the hypothesis that such 'oxidative damage' can occur in intact cells of freshwater algae and of the water flea, Daphnia magna. We will use several state-of-the-art molecular technologies (called 'omics' techniques) to obtain a comprehensive assessment of such oxidative damage as well as an assessment of potential alternative responses (as yet unidentified) in these organisms that may impact on their health. Health will also be measured in relation to growth and reproduction of these organisms. The NPs to be used will be synthesised and well characterised in relation to physical and chemical features prior to, and after, the exposure studies, including assessments of uptake into the organisms and an assessment of the relative importance of different routes of uptake. We will thus determine the nature and potency of the potential damage and risks posed by specific characteristics of the NPs to organisms in the environment, enabling targeted analyses for safety assessment screening to be developed, and provide the knowledge to reduce uncertainty in risk prediction for different species, including humans.
人造纳米颗粒(NP)可以定义为人类活动有目的地产生的非常小的材料,至少有一个尺寸在1到100 nm之间(即它们比大多数化学产品大,但比生物细胞小得多)。它们目前具有巨大的科学、技术和经济重要性,在环境技术、医疗和健康应用(例如药物输送工具、诊断、抗生素)、计算、化妆品和其他方面具有广泛的应用或潜在的应用。2006年,全球研究和开发的价值约为100亿英镑,国际纳米技术市场预计在未来十年将达到数万亿美元。鉴于这种巨大的和日益增长的重要性,值得关注的是,因为(1)排放到环境中现在正在发生,并将随着纳米技术产业的增长而以越来越快的速度增长,(二)已经证明会对人类和环境健康产生重大的不利影响,但关于它们可能造成的损害类型以及这是否会在接触时导致不利的健康影响,仍然存在很大的不确定性环境中可能达到的水平。我们致力于确保负责任地开发这些非常有益的产品。这对于确保行业和政府(最终是公众)了解NP的可能风险至关重要,以便将这些风险降至最低,并防止大规模的公众反弹,例如转基因生物。金属氧化物纳米颗粒,特别是TiO 2和CeO 2,是消费品中最广泛使用的纳米颗粒之一,尽管我们缺乏在现实条件下测量浓度的方法,但几乎可以肯定这些纳米颗粒存在于环境中。有证据表明,这两种材料都可能导致生物细胞的损伤,这是由它们产生高度破坏性形式的氧(称为活性氧)的能力引起的。然而,关于这种损害是否会发生在整个生物体,特别是在淡水环境中的信息很少,而淡水环境很可能是一个主要的接触源。关于其他毒性模式是否重要的信息也很少。我们希望测试的假设,这种“氧化损伤”可以发生在淡水藻类和水蚤,大型水蚤的完整细胞。我们将使用几种最先进的分子技术(称为“组学”技术)来获得对这种氧化损伤的全面评估,以及对这些生物体中可能影响其健康的潜在替代反应(尚未确定)的评估。健康也将根据这些生物的生长和繁殖来衡量。在暴露研究之前和之后,将合成待使用的NP,并对其物理和化学特征进行充分表征,包括评估生物体的吸收情况和评估不同吸收途径的相对重要性。因此,我们将确定纳米颗粒的特定特征对环境中生物体造成的潜在损害和风险的性质和效力,从而能够开发针对性分析,以进行安全评估筛选,并提供知识,以减少对不同物种(包括人类)的风险预测的不确定性。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Molecular toxicity of cerium oxide nanoparticles to the freshwater alga Chlamydomonas reinhardtii is associated with supra-environmental exposure concentrations.
- DOI:10.3109/17435390.2014.1002868
- 发表时间:2016
- 期刊:
- 影响因子:5
- 作者:Taylor NS;Merrifield R;Williams TD;Chipman JK;Lead JR;Viant MR
- 通讯作者:Viant MR
The critical importance of defined media conditions in Daphnia magna nanotoxicity studies.
确定的培养基条件在大型水蚤纳米毒性研究中至关重要。
- DOI:10.1016/j.toxlet.2013.08.026
- 发表时间:2013
- 期刊:
- 影响因子:3.5
- 作者:Römer I
- 通讯作者:Römer I
High Resolution STEM-EELS Study of Silver Nanoparticles Exposed to Light and Humic Substances.
- DOI:10.1021/acs.est.5b04088
- 发表时间:2016-02
- 期刊:
- 影响因子:11.4
- 作者:I. Römer;Zhi Wang;R. Merrifield;R. Palmer;J. Lead
- 通讯作者:I. Römer;Zhi Wang;R. Merrifield;R. Palmer;J. Lead
Molecular toxicity of cerium oxide nanoparticles to the freshwater alga
氧化铈纳米颗粒对淡水藻类的分子毒性
- DOI:10.6084/m9.figshare.1568131
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Taylor N
- 通讯作者:Taylor N
Synthesis and characterization of polyvinylpyrrolidone coated cerium oxide nanoparticles.
- DOI:10.1021/es402541z
- 发表时间:2013-10
- 期刊:
- 影响因子:11.4
- 作者:R. Merrifield;Z. Wang;R. Palmer;J. Lead
- 通讯作者:R. Merrifield;Z. Wang;R. Palmer;J. Lead
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Mark Viant其他文献
Mark Viant的其他文献
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{{ truncateString('Mark Viant', 18)}}的其他基金
Open source pipelines for integrated metabolomics analysis by NMR and mass spectrometry
通过 NMR 和质谱进行集成代谢组学分析的开源管道
- 批准号:
BB/M019985/1 - 财政年份:2015
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
Implementing Metabolomics Analyses into Galaxy Workflows: Towards Genome-Metabolome Large-Scale Data Fusion
在 Galaxy 工作流程中实施代谢组学分析:迈向基因组-代谢组大规模数据融合
- 批准号:
NE/K011294/1 - 财政年份:2013
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
MUSCLE: Multi-platform Unbiased-optimisation of Spectrometry via Closed Loop Experimentation
MUSCLE:通过闭环实验对光谱测量进行多平台无偏优化
- 批准号:
BB/I024085/1 - 财政年份:2012
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
From Airborne Exposures to Biological Effects (FABLE): the impact of nanoparticles on health
从空气传播到生物效应(FABLE):纳米粒子对健康的影响
- 批准号:
NE/I008314/1 - 财政年份:2011
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
Automated metabolite identification and quantification using J-resolved NMR spectroscopy
使用 J 分辨 NMR 光谱进行自动代谢物鉴定和定量
- 批准号:
BB/F016298/1 - 财政年份:2008
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
Diagnosing Toxicant Specific Disruption of Sexual Development in Wild Fish using Metabolomics
使用代谢组学诊断野生鱼类性发育的有毒特异性破坏
- 批准号:
NE/D002508/1 - 财政年份:2006
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
Diagnosing Toxicant Specific Disruption of Sexual Development in Wild Fish using Metabolomics
使用代谢组学诊断野生鱼类性发育的有毒特异性破坏
- 批准号:
NE/D002818/1 - 财政年份:2006
- 资助金额:
$ 78.53万 - 项目类别:
Research Grant
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The role of Selenoprotein I in mitigating neurodegeneration.
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